Probe Thinner Than a Hair Can Now Listen to Brain Cells and Boss Them Around at the Same Time

Figure 1. Neuropixels Opto probe design and system architecture. a, Probe Cross-Section: Shows the titanium nitride (TiN) recording sites connected to the silicon CMOS layer, alongside silicon nitride (SiN) waveguides that guide light to the emitters. b, Layout: Placement of the recording sites and two-color light emitters on the probe. c, Emitter Photos: The probe shank with two red and two blue emitters lighting up in sequence. d, Packaging: The fully assembled device package. e, System Architecture: The data system, featuring PXI modules for recording data (white) and controlling light delivery (purple).

The thing is narrower than a single human hair, and along its silicon length sit close to a thousand tiny recording points and twenty-eight microscopic windows that spit out light. Slide it into the brain of a mouse and it does two jobs that neuroscientists have, for years, been forced to do separately. It eavesdrops … Read more

Small Towns Are Vanishing From AI’s Imagination

abstract illustration about ai and small towns

Ask an AI image generator to picture Washington D.C. and it will probably give you the Mall, the monuments, the Potomac glinting in afternoon light. Ask it to picture Blacksburg, Virginia, a college town of roughly 45,000 people tucked into the Appalachian highlands, and something goes wrong. The mountains might be there, the green spaces … Read more

Teaching Machines to Listen to All Their Sensors at Once

The new method uses deep neural networks to combine data from multiple sources more effectively. Tests show it outperforms existing approaches on standard benchmarks, with strong potential for use in automation, intelligent control, and data-driven engineering.

Somewhere inside a large manufacturing plant, a turbofan bearing is beginning to fail. It will not announce this clearly. One vibration sensor picks up a faint irregularity in the x-axis; another registers a slight temperature drift; a third is recording torque anomalies that might mean nothing at all. Each sensor, considered alone, tells only a … Read more

Your Epigenetic Age Is Aging Your Brain, but Not in the Way Scientists Expected

A man covering his eyes in embarassment

Inside every cell in your body, a chemical clock is running. Not ticking exactly, more like drifting: patterns of methyl groups latching onto DNA, accumulating and shifting in ways that reflect everything you’ve done, breathed, eaten, and been exposed to across a lifetime. Researchers have spent the better part of two decades trying to read … Read more

Alzheimer’s Drugs Clear the Plaques but Leave Patients No Better Off

Drugs that target amyloid beta proteins in the brain likely have no clinically meaningful positive effects, while increasing the risk of bleeding and swelling in the brain, a new Cochrane review has found.

The brain scans look unambiguous. After 18 months of treatment, the amyloid plaques that riddle the brains of early Alzheimer’s patients are visibly reduced, sometimes dramatically so. The drug is doing exactly what it was designed to do: hunting down those sticky protein deposits and clearing them away. So why aren’t the patients getting better? … Read more

AI Disclosure Labels Reduce Trust in True Science Posts While Boosting False Ones

big yellow ai warning sign

Slapping a label on AI-generated content is the regulatory world’s current favourite answer to the misinformation problem. Transparent, scalable, required by law in China and under the EU AI Act, endorsed by Meta and X. The logic seems obvious enough: tell people a machine wrote something and they’ll scrutinise it harder. They didn’t, as it … Read more

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