Health

Researchers have determined the molecular machinery that triggers normal cardiac muscle growth and survival, and have linked defects in this complex to an inherited form of human cardiomyopathy, a type of heart failure where an enlarged heart loses its ability to pump blood. Published in the December 27, 2002 issue of the journal Cell, the study also identifies a subset of German cardiomyopathy patients with a specific gene mutation that disrupts the heart muscle’s normal stretch activity. This mutation has apparently been passed down through several generations of Northern Europeans.

A beer a day may help keep heart attacks away, according to a group of Israeli researchers. In preliminary clinical studies of a group of men with coronary artery disease, the researchers showed that drinking one beer (12 ounces) a day for a month produced changes in blood chemistry that are associated with a reduced risk of heart attack.
Their study adds to growing evidence that moderate alcohol consumption may reduce the risk of heart disease, the number one killer in the United States.

Until now, researchers thought that breast cancer nearly always began when cells in the epithelium went haywire. But new research suggests that genetic mutations can ? and do ? occur initially in a deeper layer of breast tissue, called the stroma. This presents a serious concern for physicians, who believed that breast tumors spread from epithelial tissue. “Genetic alterations in carcinomas, including breast cancers, have always been attributed to epithelial cells,” said Charis Eng, Klotz professor and director of the Clinical Cancer Genetics Program at Ohio State University. She co-authored a new study that looks at genetic mutations in breast tissue.

For some, the holiday season brings an annual rite that may feel like “compulsive shopping,” but for others, compulsive shopping is a year-round illness that seriously interferes with daily life. People with a compulsive shopping disorder often are unable to think about anything other than shopping and can’t control the impulse to purchase even useless or unwanted items. Stanford University Medical Center is continuing a multi-year clinical trial on a medication that may curb this irresistible urge.

Scientists have long recognized that, despite physical differences, all human populations are genetically similar to one another. But a new study in the journal Science concludes that populations from different parts of the world share even more genetic similarities than had previously been assumed. At the same time, researchers found that tiny differences in DNA can provide enough information to identify the geographic ancestry of individual men and women.

A combined effort between Israeli scientists has led to the discovery of a gene responsible for a type of anemia primarily found in a number of Bedouin families, called congenital dyserythropoietic anemia-1 (CDA-1). The findings, published the December issue of The American Journal for Human Genetics, could lead to effective detection and eventually treatment of the disease. In addition, understanding the role of this gene?s protein product in the body could provide important clues to other types of anemia, as well as to the general mechanisms of blood cell formation.

Instead of searching for a kidney donor, a new study suggests, one might be able to grow a new kidney. A team headed by Prof. Yair Reisner of the Weizmann Institute of Science has induced human stem cell tissue to grow into functional kidneys, and have accomplished the same with porcine stem cell tissue. Published in Nature Medicine, the method could lead to a promising solution to the severe shortage of kidney donors.