The Mouse Genome And The Measure of Man

The international Mouse Genome Sequencing Consortium today announced the publication of a high-quality draft sequence of the mouse genome – the genetic blueprint of a mouse – together with a comparative analysis of the mouse and human genomes describing insights gleaned from the two sequences. The paper appears in the Dec. 5 issue of the journal Nature. The achievement represents a landmark advance for the Human Genome Project. It is the first time that scientists have compared and contrasted the contents of the human genome with that of another mammal. This milestone is all the more significant given that the laboratory mouse is the most important animal model and is widely used in the study of human diseases.

Controlling Heart’s Irregular Rhythm No Better Than Controlling Rate

The preferred and most frequently used initial therapy for the common heart rhythm disorder atrial fibrillation (AF) is a strategy to restore and maintain a normal heart rhythm. However, a study supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health found that this “heart rhythm” strategy prevents no more deaths than the alternative, often secondary, approach to treatment which merely controls the rate at which the heart beats – and may have some disadvantages, including more hospitalizations and adverse drug effects.

Patient Safety Study Documents Medication Errors in Hospitals

According to a new national report issued today by the United States Pharmacopeia (USP)’s Center for the Advancement of Patient Safety (CAPS), administering drugs using incorrect techniques continues to be a serious cause of injury to hospital patients, increasing costs to insurers. The study collected reported medication errors voluntarily provided by 368 health care facilities nationwide, including community, government, and teaching institutions. Of the 105,603 errors documented, the vast majority were corrected before causing harm to the patient. But 2.4 percent of the total errors were more serious, resulting in patient injury, prolonged hospitalization and even death.

Addicts’ Brains Work Harder to Control Behavior

A brain-imaging study conducted at the U.S. Department of Energy’s Brookhaven National Laboratory reveals that recently abstinent methamphetamine abusers who reported they avoided harmful situations had higher resting metabolic rates in a part of the brain responsible for making decisions and modifying behaviors than those with low harm-avoidance scores. In non-addicted, comparison subjects, there was no significant association between harm avoidance and metabolism in this brain region. The findings, reported in the December 3, 2002, issue of NeuroReport, suggest that this higher-level brain center — the orbitofrontal cortex — is involved in drug addiction, and might be working extra hard in addicts trying to stay off drugs.

Satellite Could Help Predict Hantaviral Transmission Risk

Researchers report that satellite imagery could be used to determine areas at high-risk for exposure to Sin Nombre virus (SNV), a rodent-born disease that causes the often fatal hantaviral pulmonary syndrome (HPS) in humans. According to the researchers, satellite imaging detects the distinct environmental conditions that may serve as a refuge for the disease-carrying deer mice. Higher populations of infected deer mice increase the risk of HPS to humans.

Study Identifies SIDS Risk Factors Among American Indian Infants

A study of Northern Plains Indians found that infants were less likely to die of Sudden Infant Death Syndrome (SIDS) if their mothers received visits from public health nurses before and after giving birth. The study also found that binge drinking (five or more drinks at a time) during the mother’s first trimester of pregnancy made it eight times more likely that her infant would die of SIDS. Any maternal alcohol use during the periconceptional period (three months before pregnancy or during the first trimester) was associated with a six-fold increased risk of SIDS. The study also found that infants were more likely to die of SIDS if they wore two or more layers of clothing while they slept.

Evidence Lacking on Use of Routine Prostate Cancer Screening

Although screening for prostate cancer is a common part of a routine checkup for American men, a new finding issued today from the U.S. Preventive Services Task Force concludes there is insufficient scientific evidence to promote routine screening for all men and inconclusive evidence that early detection improves health outcomes. The finding is published in the December 3 issue of the Annals of Internal Medicine.

Family lives with 2,000-plus brown recluse spiders without bites

Have you had a skin wound lately and did a physician tell you a brown recluse spider was the culprit? A California study, focusing on 2,055 brown recluse spiders in a Kansas home, notes that many skin lesions are misdiagnosed by doctors as “brown recluse spider bites.” The study finds that even where brown recluses can be very common, bites from these spiders are uncommon. Moreover, the study finds that in non-endemic areas, there aren’t enough brown recluses to account for skin conditions diagnosed as “brown recluse bites.”

Diabetic gene linked to heart disease

Heart disease is the most frequent, costly and severe complication of diabetes, affecting more than 70 percent of diabetic patients. There are geographic and ethnic differences in the risk of diabetic heart disease that cannot be fully explained by differences in conventional heart disease risk factors. Using a simple blood test, researchers at the Technion-Israel Institute of Technology have identified a gene that determines which diabetes patients are at greater risk for developing heart disease. Unlike other recent breakthroughs, such as the test for C-reactive protein, the test for this gene needs to be administered only once in a patient’s lifetime.

Additive-free cigarettes may pack more toxic punch

Despite perceptions that additive-free cigarettes and the hand-rolled cigarettes from India called bidis may provide a less-toxic smoke than conventional cigarettes, new research suggests the opposite may be true. For the study, researchers asked 10 volunteers to smoke an unfiltered, additive-free American Spirit cigarette, a strawberry-flavored bidi, a non-flavored bidi and one of the participants’ own preferred brands of conventional cigarette. Results showed that two minutes after smoking the unfiltered, additive-free American Spirit cigarette or either type of bidi, participants’ plasma nicotine levels were significantly higher than when they smoked their own cigarettes. The high nicotine levels lasted longest with the American Spirit cigarette. Study results are published in the December issue of Nicotine & Tobacco Research.

Portion size matters: Given too much, we eat it

Almost nobody can stop eating at just one normal serving if there’s extra food on their plate, Penn State researchers have shown, and this tendency coupled with the spread of megaportions may be contributing to the American obesity epidemic. In the first systematic, controlled study of the response to portion size in adults, the researchers found that the bigger the portion, the more the participants ate. On average, they ate 30 percent more from a five-cup portion of macaroni and cheese than from one half its size ? without reporting feeling any fuller after eating. Dr. Barbara Rolls, who holds the Guthrie Chair of Nutrition in Penn State’s College of Health and Human Development, led the study. She says, “Men and women, normal-weight and overweight individuals, restrained and unrestrained eaters, all responded to larger portion size by eating more.”

Belief in afterlife may have biological basis

A new study by a University of Arkansas psychologist proposes that beliefs about the afterlife may amount to more than a cultural construct. They may in fact have a biological basis ? arising from the human brain’s unique ability to comprehend the mental states of other people. “The vast majority of cultures, if not all of them, have developed some theory about what happens to personal consciousness after death. Even in our own culture, 82 percent of Americans believe in some form of personal continuation after death,” said the study’s lead author. “There are superficial differences in religious beliefs between cultures, but those all arise out of the same question. Beliefs in an afterlife ? or at least thoughts about life after death ? are both universal and natural.”