Grape-seed extract may help skin wounds heal faster and with less scarring, a new study suggests. The extract seemed to aid wound healing in two ways: It helped the body make more of a compound used to regenerate damaged blood vessels, and it also increased the amount of free radicals in the wound site. Free radicals help clear potentially pathogenic bacteria from a wound.
The horse, a classic model of grace and speed on land, is now an unlikely source of inspiration for more efficient flight. So says a group of University of Florida engineers who have recreated part of a unique bone in the horse’s leg with an eye toward lighter, stronger materials for planes and spacecraft.
The third metacarpus bone in the horse’s leg supports much of the force conveyed as the animal moves. One side of the cucumber-sized bone has a pea-sized hole where blood vessels enter the bone. Holes naturally weaken structures, causing them to break more easily than solid structures when pressure is applied. Yet while the third metacarpus does fracture, particularly in racehorses, it doesn’t break near the hole – not even when the bone is subjected to laboratory stress tests. UF engineering researchers think they’ve figured out why – and they’ve built and are testing a plate that mimics the bone’s uncanny strength in a form potentially useful for airplanes and spacecraft.
In a new study, a microbiologist has discovered that the bacteria associated with almost all human ulcers – one that is also correlated with the development of certain types of gastric cancer in humans – uses hydrogen as an energy source. The finding is novel because most bacteria use sugars and other carbohydrates to grow, says Dr. Jonathan Olson, assistant professor of microbiology at North Carolina State. The human pathogen Helicobacter pylori does not.
A protein found in the eye and involved in its “immune privilege” has prevented and halted autoimmune eye disease in animal models and promises to aid in preventing and treating other autoimmune diseases, including multiple sclerosis and diabetes, according to scientists at the Schepens Eye Research Institute at Harvard University. Immune privilege is a special property of the eye that allows the eye to protect itself without the inflammation caused by the body’s conventional immune response to injury and infection.
The prospect of using bacteria to manufacture complex human proteins for use in therapeutic drugs is a step closer thanks to new research published today in Science. Researchers from Switzerland and the UK report they have engineered the bacterium Escherichia coli to carry a vital piece of cell machinery that adds sugar molecules to newly synthesized proteins by a process known as glycosylation. The finding opens up the possibility of producing complex human proteins such as Factor VIII and the hormone erythropoietin, which stimulates the production of red blood cells by stem cells in bone marrow. Both these proteins, which require the addition of sugar molecules to function properly, are currently produced by culturing mammalian cells, which can be a costly and technically difficult process.
A unique insect has given researchers the opportunity to study aging in the wild for the first time. “Aging – or senescence – has been seen under controlled conditions in the lab, but never before in insects living in their naturally evolved habitat,” says U of T zoology doctoral candidate Russell Bonduriansky. “Our study of antler flies shows these animals do age in the wild.” Bonduriansky and co-researcher Chad Brassil, both of the evolutionary ecology group at U of T, studied male antler flies to see if there was aging – a term used to denote a deterioration of the body’s vital functions, not chronological time. The two zoologists examined the flies to see if their abilities to survive to the next day and to mate deteriorated with age.
Researchers have determined the structure of a protein with a surprising feature in it: a knot. This is the first time a knot has been found in a protein from the most ancient type of single-celled organism, an archaebacterium, and one of only a few times a knot has been seen in any protein structure. This very unusual protein shape finding is a result from the NIGMS Protein Structure Initiative, a 10-year effort to determine 10,000 unique protein structures using fast, highly automated methods.
A new finding of a link between an anxiety disorder and peptic ulcer disease lends support to the view that this gastrointestinal disease and anxiety disorder may share a common link. In recent years, attention has focused on a more biological element with the identification of bacteria as a cause of peptic ulcers. “The identification of Helicobacter pylori as an infectious cause of peptic ulcer disease has been considered by many to disprove the possibility that there is an important relationship between anxiety disorders and gastrointestinal disease,” says study author Renee D. Goodwin, Ph.D., from the Department of Epidemiology at the Mailman School of Public Health at Columbia University in New York City. “Over the last several years research on the causes and treatments for peptic ulcer disease has neglected the links with psychiatric/psychological factors,” she notes.
In a critical scene in the film remake of the classic 1960s TV series “The Fugitive,” actor Harrison Ford sheds his coat and replaces it with another. This simple deception allows him to escape detection by the swarm of police officers trailing him. The African trypanosome, a blood parasite that causes African sleeping sickness, is, like Ford’s character in the film, a fugitive that changes its “coat” each time the human immune system is about to nab it. Woven of 10 million copies of a single sugar-coated molecule called a glycoprotein, the trypanosome’s surface changes every few days by virtue of a switch that activates a new gene.
In the current crisis of global biodiversity loss, the discovery of new species is a welcome addition. But the recent finding that the mountain brushtail possum, an arboreal marsupial mammal of Australian wet forests, is actually made up of two species also poses new conservation challenges. The new species is proposed in an article in the latest Australian Journal of Zoology (Volume 50, Issue 4), authored by Earthwatch-supported biologist Dr. David Lindenmayer (Australian National University) and colleagues. “Geographic dimorphism in the Mountain Brushtail Possum (Trichosurus caninus) – the case for a new species,” describes how the northern and southern populations of the mountain brushtail possum are both morphologically and genetically distinct.
Scientists have successfully restored sperm production in once-infertile mice by transplanting specialized cells that are critical to sperm development. The research, reported on the Web site of the journal Biology of Reproduction, may give scientists a better understanding of how Sertoli cells ? which surround spermatogenic stem cells ? nourish sperm production and the survival of stem cells.
For more than a decade, researchers have been trying to create accurate computer models of Escherichia coli (E. coli), a bacterium that makes headlines for its varied roles in food poisoning, drug manufacture and biological research. By combining laboratory data with recently completed genetic databases, researchers can craft digital colonies of organisms that mimic, and even predict, some behaviors of living cells to an accuracy of about 75 percent. Now, NSF-supported researchers at the University of California at San Diego have created a computer model that accurately predicts how E. coli metabolic systems adapt and evolve when the bacteria are placed under environmental constraints.
Clingy bacteria often spell trouble. Scientists have discovered how bacteria manufacture hair-like fibers used to cling to the lining of the kidney and bladder where they cause urinary tract infections (UTIs). The results are published in the Nov. 15 issue of the journal Cell. “Our findings should lead to new drugs to treat UTIs by blocking the formation of these protein fibers,” says study leader Scott J. Hultgren, Ph.D., the Helen Lehbrink Stoever Professor of Molecular Microbiology. “They also should improve our general understanding of how disease-causing bacteria build, fold and secrete proteins that enable them to cause disease.”