This new video introduces my work in the context of a hundred years of evolutionary theory and the breakthrough rejuvenation science in the present.
Health
How we know that aging is a biological function, and why it matters
This new video introduces my work in the context of a hundred years of evolutionary theory and the breakthrough rejuvenation science in the present.
Discussion
11 reader comments
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I've been expecting to see some mention by Josh concerning another recent paper out of China:
https://www.cell.com/cell/abstract/S0092-8674(25)00571-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425005719%3Fshowall%3Dtrue
The title is "Senescence-resistant human mesenchymal progenitor cells counter aging in primates". I think that the paper was freely-available for a time, but is now behind a paywall.
The paper describes genetically-modifying human mesenchymal stem cells to make them resistant to senescence, and then injecting them into aged macaques, which then experience rejuvenation of multiple tissues. The authors attribute the results partly to exosomes produced by the stem cells. Some additional results were described where the exosomes alone were observed to produce rejuvenation in mice.
A review paper summarizing the results is freely-available at:
https://cellregeneration.springeropen.com/articles/10.1186/s13619-025-00248-8
Apparently it is well-known that mesenchymal stem cell are remarkably non-immunogenic, allowing the to be used across species:
https://pmc.ncbi.nlm.nih.gov/articles/PMC1215510/#:~:text=However%20the%20normal%20process%20of,humans%20and%20in%20animal%20models.
I read the paper when it came out. It's good work, but they take the position that aging is to be resolved at the cell level, and my belief has been that aging is not cell-autonomous but is centrally coordinated. I've chosen not to write a detailed response.
No other way to account for the slamming on the brakes to life around the century mark
Hi Josh, just to know, how is Dr Harold Katcher doing? Any news? His approach was far too good not to be explored.
Here is a link to a layman's interview on Katcher as of 7 Aug 24 - https://liveforever.club/article/harold-katcher-on-the-development-results-and-future-of-e5 , followed by a link to his paper on E5 as of 11 Oct 24 (which doesn't add much to what has already been revealed. - https://onlinelibrary.wiley.com/doi/10.1111/acel.14335
Fisetin is known to have low bioavailability. It's suggested to take it with some fat, such as fish oil to improve bioavailability. However, to my knowledge this would break your fasting. Josh, can you please share how you take Fisetin during your fasting routine?
I know you were asking Josh this question, but I thought I'd put in my two bits' worth.
Valter Longo's "fasting-mimicking" diet provides many of the benefits of true fasting without the harsh exit from and re-entry to normal feeding. As it is relatively permissive of fats/oils within the caloric limits of the dietary framework, it is ready-made for optimizing fisetin absorption.
I don't mean to suggest that you switch from true fasting to the fasting-mimicking diet, but this does suggest that taking a small amount of fat/oil with some fisetin during a true fast would have relatively little impact on the beneficial effects of short-term starvation.
Interesting. I always was wondering how much calories intake would break a fast.
Maybe it's not the calories but the carbohydrates and sugar.
You might look into Valter Longo's fasting-mimicking diet. I have guidelines and suggestions at http://FMDrecipes.org
Thanks for alerting me. I wasn't aware of this issue. I chose fisetin over quercetin because I thought it was more easily absorbed, relatively.
This is wonderful, Josh. Thank you (and thank you too for pronouncing 'apoptosis' correctly :) )