I am finishing a four-day fast today. In the hope of synergizing senolytic modalities, I took 2.5 g of quercetin last night and another 2.5 g this morning. I don’t take quercetin regularly, because studies in mice show that daily administration doesn’t lengthen lifespan, and may shorten it. But for the present, quercetin is the most readily-available senolytic agent we have.
It’s my speculation that fasting might prime senescent cells for elimination, in the same way that fasting has been shown to prime cancer cells for elimination by chemotherapy or radiation. Valter Longo has been at the center of the
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