Health
The Only Experimental Subject Who Matters
We have come to expect that clinical trials require thousands of participants, tracked over years or decades.
May 16, 2017
Column
Josh Mitteldorf
Aging & evolutionary biology
Josh Mitteldorf is best known for promoting the theory that aging is not “wearing out” but rather an evolved program that limits lifespan. The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. He began blogging about aging on this site in 2012. His guidance for a long life is at AgingAdvice.org. His two books on aging are available at Amazon and elsewhere.
Mitteldorf’s PhD is in astrophysics. Since about 2020, he has taken up a new challenge as curator and critic of science on the fringe, writing about promising science that the science establishment has unjustly neglected.
In other areas of life, Mitteldorf’s two daughters were among the first girls to be adopted from China in the 1980s. He has taught a weekly yoga class for fifty years. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. Follow his other writing at mitteldorf.substack.com, and listen to his poetry on YouTube.
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Life
Prolonging Life with Fecal Transplants
A game-changing result this week from the laboratory of Dario Valenzano (Max Planck Inst). A single treatment of antibiotics in middle-aged fish followed by…
Apr 9, 2017
Health
Is fasting senolytic?
I am finishing a four-day fast today. In the hope of synergizing senolytic modalities, I took 2.5 g of quercetin last night and another 2.5 g this morning.
Apr 6, 2017
Health
Senolytics against Aging: Snapshot of a Fast-Moving Field
Aging at the cellular level is called “cell senescence”, and it contributes profoundly to whole-body aging.
Mar 28, 2017
Health
Anti-aging breakthrough? This one looks authentic
Yes, there are too many reports the last few years of people announcing the end of aging.
Mar 24, 2017
Health
New Database of Lifespan Trials
Human Ageing Genomic Resources announced last week their on-line database of animal studies that evaluated drugs and supplements for extended lifespan.
Mar 20, 2017
Health
NF-kB Beyond Inflammation
At different times, I have written about 8 different anti-inflammatory supplements, including aspirin, ibuprofen, omega 3 oils, curcumin, berberine…
Mar 8, 2017
Health
Fasting-Mimicking Diet: Can You Make it a Habit?
I was glad to see Valter Longo’s Fasting-Mimicking diet in the news again this week.
Feb 24, 2017
Health
Glycine and Mitochondria
A venerable theory of aging is the Mitochondrial Free Radical Theory (MFRTA). Mitochondria are the energy factories of the cell, where sugar is burned to create electrochemical energy.
Feb 6, 2017
Health
First Fruits of Research with Young Blood Plasma
A recurrent theme on this page is the idea that human aging is driven by a combination of proteins circulating in the blood.
Jan 23, 2017
Health
Epigenetics and the Direction of Anti-Aging Science
Dear Readers - It’s been a deeply gratifying year for me. Twenty years ago, I first started writing that aging is something the body does to itself, a body function, rather than deterioration or loss of function.
Dec 31, 2016
Health
From Santa Diego, a Jolla Xmas Gift
From the Salk Institute in La Jolla, CA came an announcement last week that the four factors previously identified to turn ordinary cells into stem cells (in cell cultures) was successfully used as a rejuvenation procedure in live mice.
Dec 23, 2016