Isoflavone-enriched soy fails to increase bone density in young women

In a study sure to disappoint the soy industry, researchers say they’ve found that soy protein enriched with isoflavones appears to have no effect on bone mineral content and bone mineral density in young women. Isoflavones are chemicals made by plants, possibly to protect them against oxidation and organisms that might attack them, and soy beans are an especially good source. Isoflavones such as genistein are structurally similar to human estrogens and for that reason have some estrogen-like properties. Scientists and drug companies have become increasingly interested in them over the past few years since the naturally occurring chemicals seem to produce positive effects in bone without the negative impact, such as cancer, that estrogens are believed to have on reproductive organs in some women.

Anchorage Area Fault May Be Due for 6 or 7 Magnitude Quake

A new study by the U.S. Geological Survey (USGS) shows that the Castle Mountain fault in south-central Alaska may be ready to produce a strong magnitude 6 to 7 earthquake. Peter Haeussler, the principal investigator in the study, said his research demonstrated that major earthquakes occurred on this fault on average every 700 years or so in the last 2,700 years, and that the last significant earthquake along the fault occurred about 650 years ago. The Castle Mountain fault is the only active fault that comes to the earth’s surface in the Anchorage region, and the eastern part of the fault produced light to moderate magnitude 5.7 and 4.6 earthquakes in 1983 and 1996.

Progress Made by Seismologists in Identifying Violations of Nuclear Test Ban

Detection techniques and technology have improved so much in recent years that seismologists now say they are able to detect and identify virtually all events that might be nuclear explosions of possible military significance under the Comprehensive Test Ban Treaty. Verification was a major issue in the U.S. Senate debate in 1999, in which American ratification of the treaty was defeated.

How you respond to high-fat diet is linked to genes

Maybe people who eat fatty foods without negative health consequences really haven’t sold their souls to the devil. They may just have good genes. The link between dietary fat intake and heart disease is hardwired into our genes, according to research reported today. “This genetic mutation helps explain why some people are able to adapt to a Western high-fat diet, while others are not able to,” says lead author Jose M. Ordovas. The fat risk is greatest for people who have a specific genetic mutation in the hepatic lipase (LIPC) gene that is involved in the way high-density lipoprotein (HDL) ? “good cholesterol” ? is metabolized. The mutation is called ?514 (C/T) LIPC, and occurs in the promoter (or expression) region of the LIPC gene encoding the ?514 T allele.

Shuttle Radar Clears the Air on Central America’s Topography

NASA’s Jet Propulsion Laboratory has completed the first comprehensive high-resolution topographic map of Central America, a region where persistent cloud cover had made high-quality satellite imagery difficult to obtain. A mosaic image created from the map, which was collected during the 2000 Shuttle Radar Topography Mission, is available on the JPL Planetary Photojournal at: http://photojournal.jpl.nasa.gov/catalog/PIA03364

Findings Reconfirm Toxicity of Pfiesteria

Well, it's not exactly helping...You’d think everyone could agree that something as grimly named as Pfiesteria would be toxic. It sure sounds toxic. But a researcher in North Carolina has been at the center of controversy for the last several years because of her claim that the organism does in fact harm fish and is responsible for periodic massive kills. A team at her own school, in fact, refuted her claims, saying when they repeated the experiments they were unable to observe the dinoflagellate microbe forming some of its previously reported toxic life-stages. The ball’s back in Dr. JoAnn Burkholder’s court today, with a new study that her team says refutes the findings published last summer stating that Pfiesteria is not toxic to fish or humans.

Prototype Developed for Ultrasonic Patch to Deliver Insulin

MiniMed has made its fortune with an insulin pump that diabetics wear around their waist and that automatically delivers controlled doses of the sugar-regulating substance to the wearer’s bloodstream. It’s a terrific product because it eliminates the need for regular syringe-based injections (though a catheter remains stuck in the patient’s belly all day long.) Combined with the company’s glucose monitor, the product works like a sort of artificial pancreas. As cool as the system is, it still involves a needle breaking skin, which can on occasion lead to infections, not to mention being a real pain. Engineers at Penn State say they’re on the road to a needle-free insulin delivery method that uses a small, ultrasonic patch to get the drug into the wearer’s blood.

Hyperbaric treatment on the cheap

Hand me a cheap plastic bag, an oxygen tank and some low-tech sensors and I’ll give you … well … I’ll give you them back. But a team from Sandia National Laboratory and a California company has combined the three into an inexpensive wound-healing device that the U.S. military says it plans to license for active and retired personnel. Think of it as a low-rent — but effective — hyperbaric chamber. But instead of costing $1 million to build and $1,500 per treatment, the whole shebang can be had for about $185.

Geneticists Find Location of Major Gene in ADHD; Also Linked to Autism

Researchers in Los Angeles have localized a region on chromosome 16 that is likely to contain a risk gene for Attention Deficit Hyperactivity Disorder, the most prevalent childhood-onset psychiatric disorder. The scientists say their finding suggest that the suspected risk gene may contribute as much as 30 percent of the underlying genetic cause of ADHD and may also be involved in a separate childhood onset disorder, autism.

New strategy may protect brain against stroke, Parkinson’s and Alzheimer’s

Federal researchers say they’ve developed several drug candidates that show promise in protecting the brain against damage from stroke, with the potential to fight chronic neurodegenerative conditions like Parkinson’s and Alzheimer’s disease as well.. The drugs, called p53 inhibitors, attack a key protein involved in nerve cell death and represent a new strategy for preserving brain function following sudden injury or chronic disease.

Monkey see: MRI technique finds big differences in human, primate sight

Don't look at me, I'm hideous.Researchers in Ohio say they’ve developed a way to use a decade-old imaging technology to directly compare the brains of monkeys and humans. Specifically, they used MRIs to compare parts of the monkey and human brains — the visual cortex — concerned with processing visual information. “Implicit in the neuroscience community was that the monkey cortex is a good model for the human cortex,” said one of the researchers. “Scientists didn’t have any choice but to make that assumption, as the monkey brain was the only model we had to work with.” But with the MRI they’ve found that there are in fact big differences.

Sandia, Cray, AMD team for Opteron-based supercomputer

Intel-rival Advanced Micro Devices got a nice science win Monday when Sandia National Laboratory and Cray Inc. said they would build a supercomputer capable 40 trillion calculations per second using AMD’s forthcoming Opteron processor. Ten thousand of them, to be precise. Total cost: $90 million. Sandia says it will use the computing heavyweight for “modeling and simulation of complex problems that were only recently thought impractical, if not impossible.”

Cancer Researchers Develop New Anti-Leukemia Strategy

Cancer researchers in San Diego have developed a 3-step process in which human leukemia cells and neighboring immune-system T cells are manipulated together in the laboratory to create a powerful and specific cancer-killing cocktail. “For reasons that are not yet entirely clear, leukemia cells fail to trigger immune responses,” said the study’s senior author, Edward D. Ball, M.D., of the Rebecca and John Moores UCSD Cancer Center. “We have developed a method in which we induce the leukemia cell to change its behavior and stimulate the immune system. At the same time, we persuade the immune system to wake up and attack only the leukemia cells.” The details of this approach, known as adoptive immunotherapy or cellular therapy, are reported in the October issue of the journal Biology of Blood and Marrow Transplantation.