amyotrophic lateral sclerosis
Disease progression halted in rat model of Lou Gehrig’s disease
Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease) is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations are the cause of disease in 5% of patients with ALS. Of immense interest,…
Loss of key protein boosts neuron loss in ALS
Amyotrophic lateral sclerosis, known as ALS or more popularly, Lou Gehrig’s disease, is a notorious neurodegenerative condition characterized by the progressive deterioration of brain and spinal cord neurons, resulting in the gradual but catastrophi…
Malfunctioning gene associated with Lou Gehrig’s disease leads to nerve-cell death in mice
PHILADELPHIA — Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) are characterized by protein clumps in brain and spinal-cord cells that include an RNA-binding protein called TDP-43. This …
Gene that causes some cases of familial ALS discovered
Using a new gene sequencing method, a team of researchers led by scientists from Johns Hopkins and the National Institutes of Health has discovered a gene that appears to cause some instances of familial amyotrophic lateral sclerosis (ALS). The f…
Genetic Abnormalities Found in Some ALS Patients
Researchers have discovered abnormalities in the chromosomes of several patients with sporadic, or non-hereditary, ALS, according to a study published in the April 22 issue of Neurology, the scientific journal of the American Academy of Neurology. ALS, or amyotrophic lateral sclerosis, is a progressive disease of the nervous system also known as Lou Gehrig’s disease.