Researchers have found that the yellow substance found in the pigment for curry prevents activation of a genetic factor leading to liver inflammation and necrosis. Despite numerous public education initiatives, alcohol abuse remains a leading cause of morbidity and mortality throughout the world. It is estimated that in the United States as many as 10 percent of men and three percent of women may suffer from persistent problems related to the use of alcohol. Alcohol affects many organ systems of the body, but perhaps most affected are the central nervous system and the liver. Almost all ingested alcohol is metabolized in the liver and excessive alcohol use can lead to acute and chronic liver disease.