telomerase
‘Immortalized’ Cells Enable Researchers to Grow Human Arteries
In a combination of bioengineering and cancer research, a team of Duke University Medical Center researchers has made the first arteries from non-embryonic tissues in the laboratory, an important step toward growing human arteries outside of the body for use in coronary artery bypass surgery.
Growing Human Skin in Laboratory Can Prematurely Age Cells
Children who receive laboratory-expanded sheets of their own skin to cover severe burns are saved from certain death, but their new skin can have the cellular age of an 80 year old, according to a study at Duke University Medical Center. The process of growing small patches of human skin into larger sheets, called tissue engineering, makes cells divide so many times that the skin becomes prematurely aged at a cellular level.
Combining chemotherapy with AZT may eradicate certain cancers
New research suggests that combining the chemotherapy drug paclitaxel with very low doses of the HIV-fighting drug AZT may shrink or even eradicate certain types of cancer tumors. Using both drugs in mice helped inhibit the enzyme telomerase, a component critical to the livelihood of some cancer cells. Telomerase helps to build and maintain telomeres ? protective strands of DNA at each end of a chromosome.