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therapeutic approaches

Liver X receptors (LXRs) and related neurological disorders.

Hormone Receptors Join Forces to Fight Brain Aging, Study Shows

Categories Brain & Behavior

Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the modified coupling reaction does not require protecting groups, is simple to perform and exhibits high reproducibility.

Chemists Unlock Efficient Way to Create Cellular Energy Molecules

Categories Health

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby facilitating PINK1/Parkin-dependent mitophagy. Additionally, HKDC1 and the VDAC proteins with which it interacts are important for repair of damaged lysosomes and maintaining mitochondria–lysosome contact. HKDC1 prevents DNA damage–induced cellular senescence by maintaining mitochondrial and lysosomal homeostasis.

A tidy cell seems to keep aging at bay

Categories Brain & Behavior, Health

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