HOW NOV-002 treatment leads to gene expression changes in SKOV3 cancer cell lines
———-
NADPH oxidase genes are up-regulated by chronic NOV-002 treatment in SKOV3 cells
NOX5 – 13.3 fold NADPH oxidase, EF calcium binding domain 5
– produces superoxide
– activated by calcium
CYBA – 2.1 fold – Cytochrome b-245 alpha polypeptide; p22 PHOX
– 22 KD subunit of NADPH oxidase
– produces superoxide anion
NCF – 2.1 fold – Neutrophil cytosolic factor 1: p47 PHOX; NOX02
– 67 KD subunit of NADPH oxidase
– produces superoxide anion
———————————–
Other genes that are up-regulated by chronic NOV-002 treatment in SKOV3 cells
IL8 – 39 fold – interleukin 8
– CXC chemokine; medicator of inflammatory response
– Chemoatrractrant and angiogenic factor
– Induced by oxidative stress
VEGFA – 3.5 fold – Vascular endothelial growth factor A
– Angiogenic factor
– Induced by oxidative stress
– Activates NADPH oxidase resulting in superoxide production
JUN – 1.8 fold – Jun oncogenes
– Activation can lead to Apoptosis
ScienceBlog.com has no paywalls, no sponsored content, and no agenda beyond getting the science right. Every story here is written to inform, not to impress an advertiser or push a point of view.
Good science journalism takes time — reading the papers, checking the claims, finding researchers who can put findings in context. We do that work because we think it matters.
If you find this site useful, consider supporting it with a donation. Even a few dollars a month helps keep the coverage independent and free for everyone.