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Washington University in St. Louis

Researchers at WashU Medicine have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer cells to display targets for the immune system to attack. Glioblastoma is one of the most aggressive cancers, as illustrated by these brain scans from a patient with glioblastoma at initial diagnosis (left) and the same patient with a recurrent tumor (right).

New Drug Strategy Makes Aggressive Brain Cancer Visible to Immune System

Categories Brain & Behavior, Health

Researchers at WashU Medicine have developed a method in mice to reduce damage from spinal cord injuries by using engineered immune cells. Mice that received this treatment showed improved recovery from their injuries, indicating potential for developing this therapy for human use.

New Immunotherapy Shows Promise in Spinal Cord Injury Recovery

Categories Brain & Behavior, Health

Artistic illustration of a human brain. Pixabay

Multiple sclerosis appears to protect against Alzheimer’s disease

Categories Brain & Behavior, Health

The top image shows fluorescently labeled cells in the spinal cord of a zebrafish recovering one week after an injury, and the bottom image shows recovery four weeks after an injury. Researchers at Washington University School of Medicine in St. Louis describe the dramatic changes within nerve cells that make regeneration possible. Such findings could inspire the development of new therapies for spinal cord injuries in people.

Zebrafish use surprising strategy to regrow spinal cord

Categories Health, Life & Non-humans

Researchers at Washington University School of Medicine in St. Louis have developed a compound that is effective against common bacteria that can lead to rare, dangerous illnesses. This image shows untreated Streptococcus pyogenes bacterial culture full of healthy microbes, labeled green (left). After treatment by GmPcide, the dish is full of dead bacteria (red; right).

New Antibiotic Compound Shows Promise Against Deadly Flesh-Eating Bacteria

Categories Health

pregnant woman talking with physician

Researchers find biological clues to mental health impacts of prenatal cannabis exposure

Categories Brain & Behavior

The remains of the most sophisticated prehistoric native civilization north of Mexico are preserved at Cahokia Mounds State Historic Site in Illinois. Archaeologist Natalie Mueller's new study casts doubt on a popular theory about why the ancient city was abandoned.

New study adds to mystery of Cahokia exodus

Categories Social Sciences

Naloxone nasal spray

New Compound Boosts Overdose-Reversing Drug’s Power

Categories Health

Nurse Megan Roberts cares for a COVID-19 patient in an intensive care unit at Barnes-Jewish Hospital in 2020. A study by researchers at Washington University School of Medicine in St. Louis shows that people with COVID-19 who used cannabis were more likely to be hospitalized and require intensive care than those who did not use the drug.

Cannabis Use Linked to Higher Risk of Severe COVID-19

Categories Health

pregnant woman talking with physician

ADHD meds may help pregnant patients control opioid use disorder

Categories Brain & Behavior, Health

An illustration depicting a fosa stalking a diademed sifaka lemur in the isolated Betampona Strict Nature Reserve in Madagascar

Lemur’s lament: when one vulnerable species stalks another

Categories Earth, Energy & Environment, Life & Non-humans

A brain scan of a neurofibromatosis type 1 (NF1) patient reveals a tumor on the optic nerve connecting the left eye to the brain (right side of the image). Researchers at Washington University School of Medicine in St. Louis have discovered that an FDA-approved epilepsy drug can prevent or slow the growth of NF1-linked optic gliomas in mice, laying the groundwork for a clinical trial.

Epilepsy drug prevents brain tumors in mice with NF1

Categories Health

Scientists at Washington University School of Medicine in St. Louis have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer’s disease plaques and the LILRB4 receptor on microglia cells (purple) activates them to clean up damaging plaques (blue) in the brain.

New Alzheimer’s Treatment Shows Promise by Activating Brain’s Immune Cells

Categories Brain & Behavior, Health

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