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Age

lymph vessels

Aging Brain’s Trash Collection System Holds Key to Memory Restoration

A cross-section of the retinal pigment epithelium in an ACE2-expressing mouse infected with SARS-CoV-2. Top image: Bright-field view with immunofluorescence showing SARS-CoV-2 N-protein (green) and complement component C3b (magenta). Bottom image: Immunofluorescence of C3b alone. Widespread C3b accumulation is visible, even though N-protein expression is limited to two small regions. Scale bars: 50 µm.

COVID-19 Infection May Accelerate Age-Related Vision Loss

B-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer’s disease brain

Ketone Bodies Are The Brain’s Natural Protein Cleanup Crew

woman's eye

New research offers hope for preventing age-related blindness

Figure 4. Effect of 2-BP treatment on senescence markers. Levels of p-p53 (A), HMGB1 (B), and lamin B1 (C) were measured in cell extracts from VSMCs. Cells were either pretreated with 2-BP for 24 hours before doxorubicin (DOX) treatment or treated with 2-BP alone for the specified durations. Protein levels were assessed using Western blotting, with representative blots shown (the red line indicates where the blot was cut) (D). Data are presented as means ± SEM from N=3 biological replicates. Statistical significance was determined using one-way ANOVA; *p

Protein Modification May Hold Key to Reversing Cellular Aging

Age-related macular degeneration affects the macula, the part of the retina that provides central vision.

Supplements slow disease progression during late stage of “dry” age-related macular degeneration

Visualization of a protein aggregation clock

A new approach to assessing aging and disease risk: The protein aggregation clock

Front cover from June’s Science Translational Medicine showing rescued retinal pigment epithelium (RPE) cells following IRAK-M gene therapy

Boosting key protein in eye cells could prevent age-related vision loss

Fluorescence microscopic image of a murine cochlea: the hair cells are marked in green, the cell skeleton in red and the cell nuclei with genetic material in blue.

New findings pave the way for hearing loss therapies

Prestin expression in OHCs from control, efavirenz, and efavirenz plus phytosterols-treated mice.

Common supplements might reduce natural hearing loss

Composite image from generative AI and Adobe Stock (Michael S. Helfenbein)

Eyes Play Quantum Chemistry with Melanin: Glasses Not Included

A man's eye being held pen by two fingers

Age-related macular degeneration a risk factor for severe COVID-19 infection

Fruit flies on a rapamycin pill

Do women age differently from men?

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