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blood

Blood–brain-barrier-crossing lipid nanoparticles (BLNPs) effectively and safely deliver mRNA to the brain via systemic administration.

Scientists Crack the Code for Delivering mRNA Medicine to the Brain

Still frame images of Digit III, the middle toe, of a live Aneides vagrans. Images were taken with the salamander in a neutral posture on a flat surface from (A) dorsal, (B) lateral, and (C) ventral views. These images show the digital sinus and the bifurcated terminal phalanx of a living salamander; the structure of these features was corroborated by our histological preparations, shown in Figures 3 and 4.

Blood-Powered ‘Hydraulic Toes’ Help Salamanders Master Tree-Top Acrobatics

Brain barrier-crossing conjugates enable the systemic delivery of large therapeutic molecules to the brain.

New Method Delivers Medicine Past Brain’s Natural Defense Shield

Nanoparticle-based drug delivery systems (DDS) containing peptides offer an innovative approach to effectively treat schizophrenia. Such DDSs hold significant potential to revolutionize therapeutic strategies against diseases that affect the central nervous system.

Nanoparticle Breakthrough Could Aid Schizophrenia Treatment

brain illustration

Researchers identify vascular changes in the brain linked to Alzheimer’s disease

Credit: Deverman lab Brain vasculature (in blue) surrounded by RNA (in orange) transcribed from the gene delivered to the brain in humanized mice using an engineered AAV targeting the human transferrin receptor.

Engineered Virus Crosses Blood-Brain Barrier, Delivers Therapeutic Genes in Mice

Person holding test tube with blood. Credit Pixabay.

Blood biomarker shows “great promise” predicting progression to Alzheimer’s in at-risk population

Illustration of a brain with a door opening

A New Mechanism for Crossing the Blood–Brain Barrier

blood brain barrier illustration

New model validates antibodies’ ability to reach the brain

blood brain barrier illustration

Rabies virus helps Alzheimer’s treatment cross blood-brain barrier

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