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Unexpected new mechanism behind rheumatoid arthritis

A team of researchers at the University of Gothenburg, Sweden, has identified an enzyme that protects against inflammation and joint destruction. Made when the researchers blocked production of the enzyme GGTase-I in transgenic mice, this unexpected...

More than allergies: Histamine may be a possible drug target for...

If you think histamines are your nemesis during allergy season, here's something that might change your perspective. New research published in the Journal of Leukocyte Biology (http://www.jleukbio.org) shows that histamine could be an important mole...

Research identifies drug target for prion diseases, ‘mad cow’

LEXINGTON, Ky. (Jan. 4, 2011) − Scientists at the University of Kentucky have discovered that plasminogen, a protein used by the body to break up blood clots, speeds up the progress of prion diseases such as mad cow disease. This finding m...

‘Long-shot’ discovery may lead to advances in treating anxiety, memory disorders

An unexpected discovery by UCLA life scientists holds promise for the future development of treatments for post-traumatic stress disorder and other anxiety disorders, and potentially for Alzheimer's disease and other memory-impairment diseases. ...

A new drug target in atherosclerosis: The anaphylatoxin C5a

For decades, doctors have looked at fitness levels, weight, and overall health risk factors for heart disease and stroke. Now, they may soon add a new risk factor to the list: activation of the complement system. The complement system is usually imp...

New prion discovery reveals drug target for mad cow disease and...

The joy of a juicy hamburger could make a comeback thanks a new discovery by scientists from the University of Kentucky. In a new research report in the December 2010 print issue of The FASEB Journal (http://www.fasebj.org), scientists found that a ...

Scientists uncover a genetic switch that turns immune responses on and...

Scientists are keeping their eye on a new discovery published in the November 2011 print issue of the FASEB Journal (http://www.fasebj.org) that explains what causes some genes to go out of control. Scientists have identified a "cellular switch," ca...

Newly discovered regulatory mechanism essential for embryo development and may contribute...

Researchers from Mount Sinai School of Medicine have identified a mechanism controlling the function of a protein that binds to DNA during embryonic development and may function to prevent abnormal tumor growth. When the protein, TCF3, is modified b...

Tumor suppressor acts as oncogene in some cancers, say Mayo Clinic...

JACKSONVILLE, Fla. -- Researchers at Mayo Clinic in Florida have found that a molecule long believed to be a beneficial tumor suppressor -- and thus a potential cancer drug target -- appears to act as an oncogene in some lethal brain tumors. ...

Link between 2 forms of ALS suggests drug target

For the first time, researchers have discovered a disease mechanism that links hereditary amyotrophic lateral sclerosis to the more common "sporadic" form of ALS -- and points to a possible therapeutic target. The findings are reported online in a...

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