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Drug a dud for diastolic heart failure

A drug that blocks the action of a key hormone did not significantly improve a set of cardiovascular outcomes for patients with diastolic heart...

Misplaced protein causes heart failure

Study shows how changes in the organized cell membrane network of heart muscle leads to heart failure Colchicine, a drug that's used to treat gout,...

MS drug shows promise for preventing heart failure from cardiac hypertrophy

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle--a disorder that...

How grapes cut heart attacks from hypertension

A study appearing in the Journal of Nutritional Biochemistry demonstrates that grapes are able to reduce heart failure associated with chronic high blood pressure...

Next-gen ‘Smart’ Stem Cells Show Promise in Heart Failure Patients

Translating a Mayo Clinic stem-cell discovery, an international team has demonstrated that therapy with cardiopoietic (cardiogenically-instructed) or "smart" stem cells can improve heart health...

U.S. hospital admission rates linked with high readmissions

High hospital readmission rates in different regions of the U.S. may have more to do with the overall high use of hospital services in those regions than with the severity of patients' particular conditions or problems in the quality of care during and...

Kidney gene implicated in increased heart failure risk

Scientists have identified the first DNA sequence variant common in the population that is not only associated with an increased risk of heart failure, but appears to play a role in causing it. The variant, a change in a single letter of the...

Structural defects precede functional decline in heart muscle

The disruption of a structural component in heart muscle cells, which is associated with heart failure, appears to occur even before heart function starts to decline, according to a new study by researchers at the University of Iowa Roy J. and L...

Exercise, the right prescription for patients with heart failure

Exercise is good medicine for heart failure patients ? even while they await heart transplantation ? according to a new statement from the American Heart Association published in today's print issue of Circulation: Journal of the American Heart Association.

Mutant protein linked to heart failure

A rare case of familial heart failure has shown that a loss of calcium regulation in heart cells may directly cause this hereditary form of the disease. The researchers who studied the case, from the Harvard Medical School lab of Christine Seidman, professor of medicine, and Jonathan Seidman, the Bugher Foundation professor of genetics, developed transgenic mice for their work that now offer a model for further investigation of heart failure and calcium signaling. The study, led by research fellow Joachim Schmitt and published in the Feb. 28 Science, suggests a specific protein target for future heart disease therapies.

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