Mouse model offers new explanation for kidney disease and failure

Mice lacking only one copy of the gene for CD2-associated protein (CD2AP) appear to be significantly more susceptible to kidney disease and failure than normal mice. Moreover, the mutation appears to impair the elimination of proteins that accumulate in the kidney, a previously unidentified process.

Study shows weight loss decreases ACE enzyme that controls blood pressure

People who find it hard to lose all the weight they want or that their doctors recommend should take heart, a North Carolina scientist says. New research suggests that losing even modest amounts of weight can pay off in better health. The study showed for the first time that shedding excess pounds decreases activity of a key enzyme known to play a central role in high blood pressure. Less body weight translates into lower blood pressure, the study found, and hence lower risks for cardiovascular disease, stroke, kidney disease and other health problems.

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