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Metabolism

Schematic summary of the glucose and lipid metabolism in fasting and fed states.

Cut the Sulfur, Shed the Fat: New Diet Approach Could Outperform Popular Weight Loss Methods

June Round inspects a dish of microbes cultured from the gut. Specific species of microbes appear to reduce the risk of diabetes and may even help restore lost pancreatic function, her results suggest.

Early-Life Gut Microbes May Protect Against Diabetes, Research in Mice Suggests

sloth hanging upside down

Climate Change Threatens Sloth Survival, Especially at High Altitudes

Scripps Research scientists discovered that specialized intestine cells (shown in green) in the C. elegans worm (gray) produce a peptide hormone that travels to the brain to control fat metabolism.

Gut molecule slows fat burning during fasting

eggs in a carton

Folate Restriction in Later Life May Promote Healthier Aging

Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the modified coupling reaction does not require protecting groups, is simple to perform and exhibits high reproducibility.

Chemists Unlock Efficient Way to Create Cellular Energy Molecules

Abstract illustration of the human body, DNA and metabolism

New Discovery Platform Unlocks Secrets of Metabolic Genes, Reveals Key Choline Transporter

White fat without the KLF-15 protein, which contains small patches of calorie-burning beige fat cells (seen above in the beige areas within the black circle). Image by Liang Li

Scientists Discover How to Make Ordinary Fat Cells Burn Calories

Animal model reseach led by Rebecca Delconte, PhD, and Joseph Sun, PhD, has shown for the first time that fasting can reprogram the metabolism of natural killer cells, helping them to survive in the harsh environment in and around tumors, while also improving their cancer-fighting ability.

Fasting primes the immune system’s natural killer cells to better fight cancer

Blood samples

Blood Variant Linked to Obesity and New Discovery Could Guide Treatment

Illustration of worm and kambucha bacteria

Kombucha Microbes Mimic Fasting Effects, Study Finds

metformin package

Metformin’s Weight Loss Effect Linked to “Anti-Hunger” Molecule Produced During Exercise

Shortening of MC4R+ primary cilia in the hypothalamus of the brain leads to middle-age obesity.

Middle-age obesity is caused by changes in the shape of neurons in the brain

Schematic representation of observed metabolic flow of bacterial metabolism F. nucleatum and S. gordonii cocultures.

When it comes to bad breath, some bacterial interactions really stink

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