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protein aggregation

c-elegans

New Screening System Could Fast-Track Discovery of Treatments for Alzheimer’s, Parkinson’s

Cells containing tau aggregates (green) before (left) and 13 hours after treatment with RING-nanobody (right)

Therapy targets and destroys tau tangles in Alzheimer’s treatment

Japanese researchers studied the effects of locally administered ASOs on mouse models of Parkinson's disease. Their research indicates that ASOs can help prevent the formation and spread of harmful alpha-synuclein aggregates in different brain regions, suggesting ASOs as a potential therapeutic strategy for preventing and controlling the progression of neurodegenerative diseases.

New Treatment Approach Shows Promise in Slowing Parkinson’s Disease Progression

Visualization of a protein aggregation clock

A new approach to assessing aging and disease risk: The protein aggregation clock

Protein clump amid neurons

The vicious cycle of protein clumping in Alzheimer’s and normal aging

a The presence of extracellular β-amyloid deposition as neuritic plaques and the intracellular accumulation of hyperphosphorylated tau as neuro fibrillary tangles remain the primary neuropathologic features for AD diagnosis, and the amyloid deposition begins with the conversion of native monomers with more α-helices to an alternative conformation with β-sheet that self-associate into ordered assemblies. b A terahertz (THz) wave at a frequency of 34.88 THz delays the fibrosis dynamic curve. c The wave decreased the aggregation speed to 80% of the case without the wave. d The wave promotes cell proliferation. e The wave loosens the dense protein conformation with transformed β-sheets to a structure with more coil and bend regions

Potential Alzheimer’s treatment would use high-frequency terahertz radiation

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