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Figure 4. Effect of 2-BP treatment on senescence markers. Levels of p-p53 (A), HMGB1 (B), and lamin B1 (C) were measured in cell extracts from VSMCs. Cells were either pretreated with 2-BP for 24 hours before doxorubicin (DOX) treatment or treated with 2-BP alone for the specified durations. Protein levels were assessed using Western blotting, with representative blots shown (the red line indicates where the blot was cut) (D). Data are presented as means ± SEM from N=3 biological replicates. Statistical significance was determined using one-way ANOVA; *p

Protein Modification May Hold Key to Reversing Cellular Aging

Visualization of a protein aggregation clock

A new approach to assessing aging and disease risk: The protein aggregation clock

Nathan Harrison, Flinders University, in Australia

Stigmatization of smoking-related diseases is a barrier to care and the problem may be on the rise

Fruit flies on a rapamycin pill

Do women age differently from men?

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