Skip to content
ScienceBlog.com
  • Featured Blogs
    • EU Horizon Blog
    • ESA Tracker
    • Experimental Frontiers
    • Josh Mitteldorf’s Aging Matters
    • Dr. Lu Zhang’s Gondwanaland
    • NeuroEdge
    • SciChi
    • The Poetry of Science
    • Wild Science
  • Topics
    • Brain & Behavior
    • Earth, Energy & Environment
    • Health
    • Life & Non-humans
    • Physics & Mathematics
    • Social Sciences
    • Space
    • Technology
  • Our Substack
  • Follow Us!
    • Bluesky
    • Threads
    • FaceBook
    • Google News
    • Twitter/X
  • Contribute/Contact

SiRNA

In the brain's immune cells, called microglia, the gene product PU.1 is associated with excessive inflammation in neurological disorders such as Alzheimer's disease. MIT researchers delivered a small interfering RNA (siRNA) via lipid nanoparticles to reduce expression of PU.1 in mice. Microglia stained for PU.1 or related markers are less evident in the bottom row, which reflects the effects of the siRNA, compared to an experimental control (top row).

Nanoparticles Target Brain Cells to Quell Alzheimer’s Inflammation

Substack subscription form sign up

Comments

  • Kalpna on Why the Weight-Loss Drug Revolution Still Needs Surgeons, Scopes and a Plan
  • Foo on A New Theory Says DMT Entities Might Be Real, and Proposes How to Test It
  • John E on A New Theory Says DMT Entities Might Be Real, and Proposes How to Test It
  • Fully Whelmed on A New Theory Says DMT Entities Might Be Real, and Proposes How to Test It
  • Tom on The Serotonin Circuit That Makes Tinnitus Louder
© 2026 ScienceBlog.com | Follow our RSS / XML feed