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SiRNA

In the brain's immune cells, called microglia, the gene product PU.1 is associated with excessive inflammation in neurological disorders such as Alzheimer's disease. MIT researchers delivered a small interfering RNA (siRNA) via lipid nanoparticles to reduce expression of PU.1 in mice. Microglia stained for PU.1 or related markers are less evident in the bottom row, which reflects the effects of the siRNA, compared to an experimental control (top row).

Nanoparticles Target Brain Cells to Quell Alzheimer’s Inflammation

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