Skip to content

Search for:

Featured Blogs
Topics
Our Substack
Follow Us!
Contribute/Contact

therapeutic approaches

Liver X receptors (LXRs) and related neurological disorders.

Hormone Receptors Join Forces to Fight Brain Aging, Study Shows

Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the modified coupling reaction does not require protecting groups, is simple to perform and exhibits high reproducibility.

Chemists Unlock Efficient Way to Create Cellular Energy Molecules

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby facilitating PINK1/Parkin-dependent mitophagy. Additionally, HKDC1 and the VDAC proteins with which it interacts are important for repair of damaged lysosomes and maintaining mitochondria–lysosome contact. HKDC1 prevents DNA damage–induced cellular senescence by maintaining mitochondrial and lysosomal homeostasis.

A tidy cell seems to keep aging at bay

Comments

Norwood johnson on Electrons in New Crystals Behave as If They Live in Four Dimensions
ScienceBlog.com on Hidden Geometry Could Finally Fix Quantum Computers
Theo Prinse on America Is Going Back to the Moon. This Time, It Plans to Stay
george w on Hidden Geometry Could Finally Fix Quantum Computers
Tom Hughes on Years of Exercise, Blood Pressure Drugs Failed to Slow Cognitive Decline in Seniors at Dementia Risk

© 2026 ScienceBlog.com | Follow our RSS / XML feed