THERAPY
Small molecule may disarm enemy of cancer-fighting p53
ORLANDO — A pioneering clinical trial is testing the effectiveness in leukemia of a small molecule that shuts down MDM2, a protein that can disable the well-known tumor suppressor p53.
Michael Andreeff, M.D., Ph.D., professor of Medicine and ch…
Approaching Treatment Involving Leg-Length Discrepancy
Leg-length discrepancy (LLD) is a condition concerning the difference in leg length which can cause issues such as disruption to normal gait patterns or pain to the spine and lower extremities.
Animal studies confirm hormone replacement can improve learning
For estrogen to enhance learning and memory, nerve cells in the brain called cholinergic neurons are essential to the process, suggest animal studies performed by researchers from the University of Pittsburgh School of Pharmacy. “Estrogen replacement in postmenopausal women has important effects on mood and cognition. This research was focused on trying to understand what estrogen does in the brain to reduce the effects on brain aging and cognitive decline,” said Robert Gibbs, associate professor of pharmaceutical sciences at the University of Pittsburgh School of Pharmacy.