Athens, Ga. — New University of Georgia research has identified a protein that can be modified to improve the effectiveness of one of the most common drugs used to treat pancreatic cancer.
The research, published in the March edition of the jour…
Leuven — Scientists attached to VIB and K.U.Leuven have succeeded in decoding a potential new anti-cancer mechanism. The researchers discovered that normalizing abnormal tumor blood vessels through HRG (histidine-rich glycoprotein) prevents metast…
Athens, Ga. — Researchers at the University of Georgia have discovered a central switch that controls whether cells move or remain stationary. The misregulation of this switch may play a role in the increased movement of tumor cells and in the agg…
(ORLANDO, Fla.) — A personalized vaccine is a powerful therapy to prevent recurrence among certain follicular lymphoma patients, according to the latest results of ongoing research led by the University of Pennsylvania School of Medicine. The new …
ANN ARBOR, Mich—University of Michigan researchers have determined that most types of melanoma cells can form malignant tumors, providing new evidence that the deadliest form of skin cancer does not conform to the increasingly popular cancer st…
The way melanoma cells use the immune system to spread and develop into lung tumors may lead to a therapy to decrease development of these tumors, according to Penn State researchers.
“Melanoma is the most aggressive and metastatic form of skin ca…
Scientists at Washington University School of Medicine in St. Louis have discovered a new drug target that could improve the effectiveness of radiation for hard-to-treat cancers.
The finding, published in the Journal of the National Cancer Institu…
Researchers are working to develop a non-surgical approach to brain cancer that uses radiation and the injection of specially cultured bone marrow cells into the tumor. The combination sets in motion a local and systemic immune response to kill surviving tumor cells. The novel approach has provided promising results in a study on rats, described in the March 3 issue of the Journal of Immunotherapy. Human trials are expected to begin within the year.
Researchers at Washington University School of Medicine in St. Louis have found that a protein called cytidine uridine guanosine binding protein-2 (CUGBP2) can destroy several different types of cancer cells. When the team inserted the protein into cultured tumor cells, more than 70 percent self-destructed. The researchers found that CUGBP2 helps regulate production of cyclooxygenase-2, (COX-2), which is better known as a key culprit in arthritis.
Despite advances in neurosurgery and radiation techniques, the prognosis for patients with intracranial glioma remains devastating. Now, researchers have identified a possible new treatment strategy for this common type of malignant brain tumor. Two studies funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) show that, in a mouse model, neural stem cells (NSCs) can be used to deliver therapeutic agents capable of killing glioma cells and their migrating tumor cells.
Researchers in Los Angeles have combined a special protein that targets cancer cells with neural stem cells to track and attack malignant brain tumor cells. Glioblastoma multiforme, or gliomas, are a particularly deadly type of brain tumor. They are highly invasive with poorly defined borders that intermingle with healthy brain tissue, making them nearly impossible to remove surgically without catastrophic consequences. Furthermore, cells separate from the main tumor and migrate to form satellites that escape treatment and often lead to recurrence.
Using a common diabetes drug, researchers in Los Angeles have successfully treated pituitary tumors that cause a potentially life-threatening condition known as Cushing’s syndrome. The most common type of Cushing’s syndrome is caused by prolonged high-level exposure of a hormone called ACTH (adrenocorticotropin), which is secreted in excess by tumors of the pituitary gland, situated at the base of the brain and, which controls growth, metabolism and reproduction. Although the disorder is rare, it affects more women than men by a ratio of 5:1. Symptoms include weight gain with rounding of the face; increased fat in the neck; thinning skin; excess hair growth on the face neck, chest abdomen and thighs; muscle weakness and bone loss (osteoporosis); high blood sugar; diabetes; and high blood pressure.