I have been enthusiastic about telomerase therapies for anti-aging since 2003. But if I can’t change my mind as new data appears, what’s the point of being a scientist? I still believe that lengthening telomeres is a net benefit, but the potential for added years is modest, and there are probably risks and tradeoffs. The study that has most influenced me is this one, implying that telomerase affects epigenetics (through methylation) in ways that accelerate aging. My theory is that the unexpected relationship between telomerase and methylation is an example of antagonistic pleiotropy, but pleiotropy in a very different sense
If our reporting has informed or inspired you, please consider making a donation. Every contribution, no matter the size, empowers us to continue delivering accurate, engaging, and trustworthy science and medical news. Independent journalism requires time, effort, and resources—your support ensures we can keep uncovering the stories that matter most to you.
Join us in making knowledge accessible and impactful. Thank you for standing with us!