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Washington University in St. Louis

Researchers at WashU Medicine identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study they describe a brain pathway that starts with neurons (labeled in green, above) that sense inflammation signals, and the researchers were able to treat the loss of motivation by blocking this pathway.

Brain Pathway Links Inflammation to Loss of Motivation in Advanced Cancer

Categories Brain & Behavior, Health

WashU Medicine researcher Kanta Horie, PhD, places a sample in a mass spectrometer that measures protein levels in blood plasma and other fluids. Horie co-led the development of a blood test for Alzheimer’s disease that diagnoses and stages the disease by using mass spectrometry to measure the level of a protein called MTBR-tau243.

Highly accurate blood test diagnoses Alzheimer’s disease, measures extent of dementia

Categories Brain & Behavior, Health

lymph vessels

Aging Brain’s Trash Collection System Holds Key to Memory Restoration

Categories Brain & Behavior

Biomolecular condensates often appear like soap bubbles but are actually more like Silly Putty, featuring mostly elastic and viscous behaviors on different time scales. WashU researchers have devised a method to image the internal organization within condensates to arrive at a structural explanation for condensate viscoelasticity. (Image: Shutterstock)

Scientists Unveil the Hidden World of Cellular ‘Silly Putty’

Categories Health

protest

Expert: There Is No Such Thing as ‘Illegal’ Protest

Categories Social Sciences

Primary Prevention trial participant Hannah Richardson, 24, undergoes a clinical exam given by WashU Medicine neurologist Nupur Ghoshal, MD, PhD. The international trial, led by WashU Medicine, aims to determine whether stopping the early molecular changes that lead to symptomatic Alzheimer’s disease can prevent the disease from ever taking hold.

Young Adults Join Battle Against Alzheimer’s in Historic Prevention Trial

Categories Brain & Behavior

sickle cell blood cells

Sickle Cell Disease Ages Brain Years Ahead of Time

Categories Brain & Behavior

An illustration depicting a human brain with colorful, pulsating waves emanating from different regions

Brain Structure May Predispose Teens to Early Substance Use

Categories Brain & Behavior

In the Alzheimer’s affected brain, abnormal levels of the amyloid-beta protein clump together to form plaques (brown) that collect between neurons and disrupt cell function. Abnormal collections of the tau protein accumulate and tangle (blue) within neurons, harming synaptic communication between nerve cells. Image courtesy of National Institute on Aging, NIH.

Novel Nanofiber Vaccine Aims to Prevent Dementia Without Inflammation

Categories Brain & Behavior, Health, Technology

Researchers at WashU Medicine have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer cells to display targets for the immune system to attack. Glioblastoma is one of the most aggressive cancers, as illustrated by these brain scans from a patient with glioblastoma at initial diagnosis (left) and the same patient with a recurrent tumor (right).

Brain Tumors Hijack Body’s Clock to Fuel Growth

Categories Health

woman at food pantry

Volunteering reduces rate of aging, study finds

Categories Health

Obese man illustration from Pixabay

Deep Belly Fat Linked to Early Signs of Alzheimer’s Decades Before Symptoms

Categories Brain & Behavior, Health

spinal fluid

Brain Fluid Analysis Reveals Potential Drug Targets for Alzheimer’s

Categories Brain & Behavior, Health

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