Isoflavone-enriched soy fails to increase bone density in young women

In a study sure to disappoint the soy industry, researchers say they’ve found that soy protein enriched with isoflavones appears to have no effect on bone mineral content and bone mineral density in young women. Isoflavones are chemicals made by plants, possibly to protect them against oxidation and organisms that might attack them, and soy beans are an especially good source. Isoflavones such as genistein are structurally similar to human estrogens and for that reason have some estrogen-like properties. Scientists and drug companies have become increasingly interested in them over the past few years since the naturally occurring chemicals seem to produce positive effects in bone without the negative impact, such as cancer, that estrogens are believed to have on reproductive organs in some women.

Findings Reconfirm Toxicity of Pfiesteria

Well, it's not exactly helping...You’d think everyone could agree that something as grimly named as Pfiesteria would be toxic. It sure sounds toxic. But a researcher in North Carolina has been at the center of controversy for the last several years because of her claim that the organism does in fact harm fish and is responsible for periodic massive kills. A team at her own school, in fact, refuted her claims, saying when they repeated the experiments they were unable to observe the dinoflagellate microbe forming some of its previously reported toxic life-stages. The ball’s back in Dr. JoAnn Burkholder’s court today, with a new study that her team says refutes the findings published last summer stating that Pfiesteria is not toxic to fish or humans.

New strategy may protect brain against stroke, Parkinson’s and Alzheimer’s

Federal researchers say they’ve developed several drug candidates that show promise in protecting the brain against damage from stroke, with the potential to fight chronic neurodegenerative conditions like Parkinson’s and Alzheimer’s disease as well.. The drugs, called p53 inhibitors, attack a key protein involved in nerve cell death and represent a new strategy for preserving brain function following sudden injury or chronic disease.

Researchers Determine How ‘Hospital Staph’ Resists Antibiotics

Drug-resistant staph infections are a major concern to health care providers. Hospitals in particular have become home to some strains of Staphylococcus aureus that resist every known antibiotic, including the last-resort vancomycin. But two researchers say they’ve discovered just how so-called “Hospital staph” develops resistance, potentially opening the door for development of new drugs that beat it to the punch.

Gene therapy appears to help cancer pain

It’s one of those stories that simultaneously gives great hope but also a little dread. Researchers in Pennsylvania say they’ve successfully stimulated the production of a pain-blocking protein in mice by using a modified herpes virus to attach the appropriate genes onto the animals’ DNA. That’s potentially terrific news. If the same technique held true in humans, it could offer a new way to treat the devastating pain associated with some forms of cancer, such as bone cancer. Of course, a hell of a lot of mice were bred specifically develop the extremely painful bone tumors, just so the technique could be tested. It’s no doubt a necessary sacrifice, but one that shouldn’t be overlooked entirely. You don’t have to be a wacko member of PETA to spare a thought for the millions of mice and other lab animals that are sacrificed each year so humans can live healthier lives.

New prion test faster, more accurate

Researchers say they’ve developed a new test for prions that improves the accuracy and speed with which the malformed and infectious proteins can be detected. Prions cause neurodegenerative diseases in sheep, deer and elk, plus Mad Cow disease in cattle and Creutzfeldt-Jakob in humans.

Cell keeps spare set of DNA to ensure offspring gets fresh start

This is a little complex, but bear with us. Nearly all cells house their DNA inside a nucleus. But a little one-celled critter called Tetrahymena houses different versions of its DNA in each of its two nuclei. Researchers have found that the smaller nucleus (called the micronucleus) just keeps the cell’s full genome safe, acting as a sort of “lock box.” The larger nucleus (called the macronucleus) uses the DNA to regulate the cell’s life functions. When the cell mates to create a new generation, the two work together to compare the cell’s current DNA against what’s been stored in the lock box. If any foreign genes have snuck in (like from a virus) they nuclei eliminate it, to make sure baby gets a fresh start. Pretty neat, with possible implications for larger organisms, too.

Biologist Offers a Solution to the ‘Freeloaders Paradox’

Freeloaders ?? individuals eager to join social groups, but who once in, tend to avoid pulling their fair share of the chores ?? have long posed something of a problem for evolutionary biologists. In theory, because freeloaders don?t expend the efforts and energy of their more civic-minded neighbors, they should be able to translate that energy into more offspring, spreading their “slacker genes” and overrunning the world with offspring of similar ilk. But that doesn’t happen, and an Arizona researcher thinks she knows why.

Vet develops cheap manatee chow for injured animals

Fifty pounds of romaine lettuce makes enough Caesar salad for a hundred people, but it?s just a one-day food supply for a manatee in captivity. To feed the endangered aquatic mammals more economically while they recover from injuries or medical treatment, a University of Florida veterinarian has developed a new manatee chow that costs one-tenth the price of lettuce. The discovery comes at a time when manatee injuries and subsequent deaths have reached record rates. In 1986, 122 manatees died in Florida. Fifteen years later, that number climbed to 325.

Bloodworm shows new use for copper

The lowly and somewhat gruesome bloodworm may have a few lessons to teach material scientists.The critter apparently is the first ever to be found to use a copper-containing mineral structure as part of its skeleton. The finding is remarkable first because the amount of copper detected in the jaw tip of the marine worm would normally be toxic to an organism. Second, the copper also occurs in non-mineral form in the bloodworm jaw where it may act as a sort of bridge, cross-linking long chains of fibrous proteins. And that has appealing commercial posibilities. “The marriage of protein with copper mineral as well as with bound copper ions is an intriguing concept per se but may also serve as a design prototype for new materials that need to be hard, lightweight, and durable.”

Dinosaur mummy sheds light on look, feel of prehistory

Turns out all those CGI cats working on the “Jurassic Park” and “Lost World” films were pretty spot on. A mummified dinosaur uncovered in Montana looks shockingly like the creatures depicted on the big screen. Almost too much alike. Hey, wait a minute….

Eczema all about infection

Researchers say they’ve found that people with atopic dermatitis, a.k.a. eczema, are susceptible to bacterial infections in their skin because their bodies don’t produce enough of two antimicrobial peptides. The findings show that while an allergic reaction can cause a rash, true eczema is all about infection. And medicines containing or inducing the peptides could be used to fight the disorder, which affects millions worldwide.

Research that matters

New Scientist reports on a year-long study to find the world’s funniest joke. The Internet-based project was coordinated by psychologist Richard Wiseman and colleagues at the University of Hertfordshire, U.K. and involved more than 2 million votes on 40,000 submissions. The goal was to identify universal aspects to humor, which could one day allow computers to devise truly funny jokes. Before we get to the winner, an interesting aside is that the team found in the process the world’s funniest animal: the duck. “If you’re going to tell a joke involving an animal, make it a duck,” Wiseman says. Now to the ultimate rib-tickler, which folks from Asia to Africa, the States to Siberia all seemed to enjoy. A couple of New Jersey hunters are out in the woods when one of them falls to the ground. He doesn’t seem to be breathing, his eyes are rolled back in his head. The other guy whips out his cell phone and calls the emergency services. He gasps to the operator: “My friend is dead! What can I do?” The operator, in a calm soothing voice, says: “Just take it easy. I can help. First, let’s make sure he’s dead.” There is a silence, then a shot is heard. The guy’s voice comes back on the line. He says: “OK, now what?” Thank you folks, I’ll be here all week.

New worm a real bear

PC users of the world beware! A new worm called BugBear is making the rounds, and New Scientist says it reflects a worrying new trend in virus code. Instead of disabling your computer, or turning it into a denial of service pod to flood other machines with garbage, BugBear contains a Trojan horse program that can collect credit card details, passwords and other private information stored from a computer and send it to a hacker. “When run, the Trojan disables anti-virus programs running on your machine,” New Scientists says. “It then installs a ‘keyboard sniffing’ program that remains in the background and copies every keystroke on your keyboard and saves them to a file. At some point later it opens a network connection and transmits the file to its creator, or bundles it up and sends it out as an email.” One side effect of the worm is that it tries to mail itself to any other machines on your network, including printers. So if you see unexpected, long junk printouts spewing for the LaserJet, you ought to get checked for infection.

See also:
>>BugBear at Sophos