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Cell biology

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby facilitating PINK1/Parkin-dependent mitophagy. Additionally, HKDC1 and the VDAC proteins with which it interacts are important for repair of damaged lysosomes and maintaining mitochondria–lysosome contact. HKDC1 prevents DNA damage–induced cellular senescence by maintaining mitochondrial and lysosomal homeostasis.

A tidy cell seems to keep aging at bay

Cell atlas of the mouse brain determined by a genome-scale imaging technology called MERFISH. Shown is one sagittal section with cells colored by category. Image courtesy of Xiaowei Zhuang

Demystifying a mammal’s brain, cell by cell

An Anthrobot is shown, depth colored, with a corona of cilia that provides locomotion for the bot

Scientists build tiny biological robots from human cells

A lethal parasite’s secret weapon: infecting non-immune cells

A green anole lizard regenerating its tai.

Researchers unlock mystery of cartilage regeneration in lizards

Elderly man's hands. Pixabay

A novel theory of aging — independent of damage accumulation

Scientists from the Milner Centre for Evolution have uncovered a new quality control system that removes damaged cells from early developing embryos.

Scientists discover new embryonic cell type that self-destructs to protect the developing embryo

Octopuses have complex “camera” eyes, as seen here in a juvenile animal

Octopus camouflage ability transferred to human skin cells

Image of human breast cancer cells showing A) immunosuppressive macrophages near tumor connective tissue, and B) immunostimulatory macrophages near tumor nests. Credit: Nir Ben Chetrit.

Scientists Locate Gene Activity and Proteins Across Tissues

Using these engineered proteins, researchers can record histories that reveal when certain genes are activated or how cells respond to a drug.

Scientists read cell history via protein chains

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