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Cellular senescence

Figure 4. Effect of 2-BP treatment on senescence markers. Levels of p-p53 (A), HMGB1 (B), and lamin B1 (C) were measured in cell extracts from VSMCs. Cells were either pretreated with 2-BP for 24 hours before doxorubicin (DOX) treatment or treated with 2-BP alone for the specified durations. Protein levels were assessed using Western blotting, with representative blots shown (the red line indicates where the blot was cut) (D). Data are presented as means ± SEM from N=3 biological replicates. Statistical significance was determined using one-way ANOVA; *p

Protein Modification May Hold Key to Reversing Cellular Aging

senolytic infographic

SGLT2 Inhibitors: A Novel Approach to Combat Aging

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby facilitating PINK1/Parkin-dependent mitophagy. Additionally, HKDC1 and the VDAC proteins with which it interacts are important for repair of damaged lysosomes and maintaining mitochondria–lysosome contact. HKDC1 prevents DNA damage–induced cellular senescence by maintaining mitochondrial and lysosomal homeostasis.

A tidy cell seems to keep aging at bay

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