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molecular mechanism

Postdoctoral research associate Samuel Eastman (left), 2024 Princeton graduate Kaeli Ficco (right), and their colleagues uncovered a mechanism by which soil bacteria can modulate plant immunity.

Scientists Uncover How Beneficial Bacteria Help Plants Balance Growth and Defense

Kaempferol produces an anti-inflammatory effect that combats the immune response seen in food allergies by increasing Raldh2 expression in intestinal dendritic cells in a concentration-dependent manner, thus accelerating regulatory T-cell development.

Flavonoid kaempferol: Nature’s Key to Unlocking Anti-Allergic Defenses

From left to right, the experts Leticia Pérez-Sisqués, Genís Campoy-Campos, Almudena Chicote-González, Cristina Malagelada, Júlia Solana-Balaguer, Jordi Alberch and Pol Garcia-Segura, from the Institute of Neurosciences of the University of Barcelona (UBneuro).

Researchers identify a new molecular mechanism that could help design future therapies to treat Alzheimer’s disease

Researchers investigated the function of PQBP3, a protein that was previously linked to certain neurodegenerative diseases, and unveiled its role in maintaining the integrity of the nuclear membrane. In senescent (aged) cells, PQBP3 concentration is decreased thereby promoting Lamin B1 degradation, and PQBP3 leaks from its typical place in the nucleolus to the cytosol, which in turn causes the nuclear membrane to get destabilized.

Protein Discovery Illuminates Link Between Aging and Brain Diseases

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