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neurodegenerative diseases

lymph vessels

Aging Brain’s Trash Collection System Holds Key to Memory Restoration

Researchers at MIT have devised a simplified process to convert a skin cell directly into a neuron. This image shows converted neurons (green) that have integrated with neurons in the brain’s striatum after implantation.

Scientists Crack Code to Transform Skin Cells Directly into Neurons

(a) MRI shows electrode placement (SMA02, T11-T12) near the conus medullaris (yellow, below T12). Wireless stimulators targeted leg muscles (SMA03 example: 5mA/40Hz/400μs right, 5.5mA/40Hz/400μs left). (b) 3D motion capture and EMG recorded 7 leg muscles (ST, BF, VL, RP, RD, G, TA) during walking. (c) Study timeline. (d) Decreased EMG response with increasing SCS frequency (SMA01) indicates sensory-driven motor neuron recruitment. (e) Passive knee movement (SMA03) using a robotic system. Angle-dependent spinal reflexes (rectus femoris EMG shown) confirm sensory afferent activation by SCS. (Insets show reflexes at max extension/flexion).

Shocking the Spine Back to Life

ziziphus jujuba

Ancient Chinese Seed Shows Surprising Power to Prevent and Reverse Dementia in Mice

c-elegans

New Screening System Could Fast-Track Discovery of Treatments for Alzheimer’s, Parkinson’s

This inoculated MacConkey agar culture plate cultivated colonial growth of Gram-negative, small rod-shaped and facultatively anaerobic Klebsiella pneumoniae bacteria. K. pneumoniae bacteria are commonly found in the human gastrointestinal tract, and are often the cause of hospital acquired, or nosocomial infections involving the urinary and pulmonary systems.

Gut bacteria implicated in Alzheimer’s

Liver X receptors (LXRs) and related neurological disorders.

Hormone Receptors Join Forces to Fight Brain Aging, Study Shows

From left to right, the experts Leticia Pérez-Sisqués, Genís Campoy-Campos, Almudena Chicote-González, Cristina Malagelada, Júlia Solana-Balaguer, Jordi Alberch and Pol Garcia-Segura, from the Institute of Neurosciences of the University of Barcelona (UBneuro).

Researchers identify a new molecular mechanism that could help design future therapies to treat Alzheimer’s disease

The brain of a 7-day-old fruit fly with Tau expressed in a neuronal circuit used by the fly in olfactory memory. The green outlines the neurons, which are starting to swell and degenerate due to the Tau protein. The red shows where Tau is building up in clusters along the neurons, starting to form the clumps that eventually become rope-like fibrils.

Promising ‘first’ in Alzheimer’s drug development

Finger prick blood test. Pixabay

Diabetes Drugs May Lower Risk of Dementia and Parkinson’s, Study Finds

Researchers investigated the function of PQBP3, a protein that was previously linked to certain neurodegenerative diseases, and unveiled its role in maintaining the integrity of the nuclear membrane. In senescent (aged) cells, PQBP3 concentration is decreased thereby promoting Lamin B1 degradation, and PQBP3 leaks from its typical place in the nucleolus to the cytosol, which in turn causes the nuclear membrane to get destabilized.

Protein Discovery Illuminates Link Between Aging and Brain Diseases

structure of CNDR-51997

NIH Awards $6.9 Million to Advance Promising Alzheimer’s Treatment

Preventing Parkinson’s disease may lie in seaweed antioxidants

Preventing Parkinson’s disease may lie in seaweed antioxidants

Researchers demonstrate exosomes loaded with fluorescent sensors that can pass through the blood-brain barrier (BBB) where the sensors light up in the presence of neurotransmitters linked to Alzheimer’s disease in the brain.

Improving Alzheimer’s disease imaging — with fluorescent sensors

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