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neuroinflammation

Illustration of the link between air pollution and autism spectrum disorder (ASD).

Air Pollution During Pregnancy and Early Childhood Linked to Increased Autism Risk

Lead researcher Ashok Shetty has filed a patent on the intranasal application of neural stem cell-derived extracellular vesicles for treating Alzheimer’s and other neurological and neurodegenerative disorders.

Simple Nasal Spray Could Help Slow Alzheimer’s Disease, Study Shows

Arachidonic acid, which is released from phospholipid membranes, is metabolized to various epoxyeicosatrienoic acid (EET) compounds and subsequently to dihydroxyeicosatrienoic acids (diHETrE). This study revealed that high levels of 11,12- diHETrE in umbilical cord blood are associated with ASD symptoms, such as social affect (SA) and adaptive functioning. Additionally, lower levels of 8,9-diHETrE impacted repetitive/restrictive behaviors (RRB).

Fatty acids in umbilical cord blood might cause autism spectrum disorder

brain illustration

New Brain Injury Atlas Paves Way for Personalized TBI Treatments

In the brain's immune cells, called microglia, the gene product PU.1 is associated with excessive inflammation in neurological disorders such as Alzheimer's disease. MIT researchers delivered a small interfering RNA (siRNA) via lipid nanoparticles to reduce expression of PU.1 in mice. Microglia stained for PU.1 or related markers are less evident in the bottom row, which reflects the effects of the siRNA, compared to an experimental control (top row).

Nanoparticles Target Brain Cells to Quell Alzheimer’s Inflammation

Brain illustration

New biomarker, potential therapy for Multiple Sclerosis and related neuro disorders

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