Aging & evolutionary biology
Josh Mitteldorf is best known for promoting the theory that aging is not “wearing out” but rather an evolved program that limits lifespan. The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. He began blogging about aging on this site in 2012. His guidance for a long life is at AgingAdvice.org. His two books on aging are available at Amazon and elsewhere.
Mitteldorf’s PhD is in astrophysics. Since about 2020, he has taken up a new challenge as curator and critic of science on the fringe, writing about promising science that the science establishment has unjustly neglected.
In other areas of life, Mitteldorf’s two daughters were among the first girls to be adopted from China in the 1980s. He has taught a weekly yoga class for fifty years. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. Follow his other writing at mitteldorf.substack.com, and listen to his poetry on YouTube.
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In a recent study of heart medications (REDUCE-IT), mineral oil was used as a “placebo”. Mineral oil is not a biological substance, and the body rejects it with nausea and diarrhea.
Jun 16, 2023
Experience tells us that it is much easier to extend median lifespan than maximum lifespan.
Mar 13, 2023
One cold weekend in the fall of 1985, professor Stanley Pons of the University of Utah asked one of his undergraduate students to look in on an experiment that he and professor Martin Fleischmann had been conducting in their spare time.
Feb 8, 2023
I begin from the paradigm that aging is not a random process but an adaptation, a programmed self-destruction.
Jan 16, 2023
It seems too simple to explain much, but according to a study out of Northwestern University, large proteins are more prevalent in young animals compared to old.
Dec 13, 2022
Can methylation clocks be relied on in this context? The earliest clocks were trained on biological age only, and yet they predicted morbidity and mortality better than biological age.
Oct 20, 2022
Example: This is what the insulin protein looks like after it is folded up.
Sep 29, 2022
Rebalancing proteins in the blood is the single most promising strategy for age reversal in the present environment.
Sep 11, 2022
Sickening by John Abramson, MD. Mariner Books, 2022, ISBN 978-1328957818 This book describes the top-to-bottom control over medical research and its dissemination exerted by large drug manufacturers.
Jul 25, 2022
Harold Katcher’s patent was unveiled last week, and it’s not what I thought it would be.
Jul 22, 2022
Preliminary results from lifespan studies with E5 Harold Katcher has developed a protocol for lab rats using intravenous injection with a blood plasma fraction…
Jun 26, 2022
I have promoted the idea that aging is programmed and that the program is epigenetic.
Jun 20, 2022
