Health
Lifespan of Harold Katcher’s Rats
Preliminary results from lifespan studies with E5 Harold Katcher has developed a protocol for lab rats using intravenous injection with a blood plasma fraction…
Jun 26, 2022
Column
Josh Mitteldorf
Aging & evolutionary biology
Josh Mitteldorf is best known for promoting the theory that aging is not “wearing out” but rather an evolved program that limits lifespan. The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. He began blogging about aging on this site in 2012. His guidance for a long life is at AgingAdvice.org. His two books on aging are available at Amazon and elsewhere.
Mitteldorf’s PhD is in astrophysics. Since about 2020, he has taken up a new challenge as curator and critic of science on the fringe, writing about promising science that the science establishment has unjustly neglected.
In other areas of life, Mitteldorf’s two daughters were among the first girls to be adopted from China in the 1980s. He has taught a weekly yoga class for fifty years. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. Follow his other writing at mitteldorf.substack.com, and listen to his poetry on YouTube.
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Health
Is there a master timekeeper, upstream of the methylation clock?
I have promoted the idea that aging is programmed and that the program is epigenetic.
Jun 20, 2022
Health
I recommend this book for every life extensionist
Readers of this blog are interested in life extension. We relish the experience of being alive, and we struggle with dread of death, and there is diversity among us how much relish and how much dread we harbor.
Jun 1, 2022
Health
GlyNAC improves biomarkers in humans and extends lifespan in rodents
Antioxidants proved a bust for life extension almost 25 years ago, but glutathione stands out as an exception.
Mar 31, 2022
Health
Can we trust methylation clocks?
A methylation clock is an empirical construct. There is no understanding of physiology or metabolism built into the process.
Mar 3, 2022
Health
Love and Longevity
One reason I love this topic is that I have centered my academic career around the thesis that aging is a socially-evolved phenomenon.
Feb 14, 2022
Health
Omicron Origins—Omicron Optimism
The genome of Omicron has taken the community of public health scientists by surprise.
Jan 6, 2022
Health
Immune senescence, Christian theology, and the Spike protein
One of the things that happens to our immune systems with age is that a preponderance of naïve B-cells (in youth) gives way to a diverse body of memory B-cells (in older adults), each trained to respond to a specific pathogen from the past.
Dec 17, 2021
Health
A New Approach to Methylation Clocks
A new approach to methylation clocks from Morgan Levine uses massive computer resources and sophisticated mathematics.
Sep 6, 2021
Health
Statistical Fraud in the FDA Vaccine Approval Process
The Pfizer vaccine is on a fast track for FDA approval, hearings possible today according to the NYTimes.
Aug 22, 2021
Health
Letter to my readers
I struggled since childhood with night terrors, about death as an eternal void. My csreer as aging scientist helped me to crack that open, then gain insight through meditation practice.
Aug 10, 2021
Health
Is aging inevitable?
A new study has appeared to support an old idea: Aging is inevitable and immutable, so anti-aging research is doomed in advance to failure.
Jun 17, 2021