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Aging

Zombie cells

Unveiling Zombie Cell Biomarkers and Mitochondrial Rogue Behavior

Brain changes behind pain sensitivity may affect older women more

Illustration of circadian clocks in a cell

Time Warp: Resveratrol Tweaks Tiny Timers Inside Cells, Hints at Anti-Aging Hope

Mice illustration

Life span increases in mice when specific brain cells are activated

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby facilitating PINK1/Parkin-dependent mitophagy. Additionally, HKDC1 and the VDAC proteins with which it interacts are important for repair of damaged lysosomes and maintaining mitochondria–lysosome contact. HKDC1 prevents DNA damage–induced cellular senescence by maintaining mitochondrial and lysosomal homeostasis.

A tidy cell seems to keep aging at bay

elderly man lifting weights

Exercise-induced Pgc-1α expression inhibits fat accumulation in aged skeletal muscles

Man smoking. Unsplash

Smoking causes brain shrinkage

Fat fly

Fat flies live longer on a diet at any age

Lab mouse.

Mice eating less of specific amino acid — overrepresented in diet of obese people — live longer, healthier

Saturated fat may interfere with creating memories in aged brain

Illustration of a heart and stethoscope

Transfer of ageing: New drug class prevents key ageing mechanism in organ transplants

Pregnant woman sitting in a wheat field. Pixabay

How pre-eclampsia accelerates aging in womenHow pre-eclampsia accelerates aging in women

University of Rochester researchers successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Longevity gene from naked mole rats extends lifespan of mice

metformin package

How diabetes drug metformin extends lifespan in lab models

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