Transplanting fat may be effective treatment for metabolic disease

Transplanting fat may treat such inherited metabolic diseases as maple syrup urine disease (MSUD) by helping the body process the essential amino acids that these patients cannot, according to Penn State College of Medicine researchers. … Read more

Splitting donated livers shown to be safe, allowing doctors to save 2 lives from single organ

Split liver transplantation carries no increased risk of failure in either recipient, allowing surgeons to safely save two lives from a single donated organ (graft), according to new research from Boston Children’s Hospital published online … Read more

Green tea flavonoid may prevent reinfection with hep C after transplant

German researchers have determined that epigallocatechin-3-gallate (EGCG)—a flavonoid found in green tea—inhibits the hepatitis C virus (HCV) from entering liver cells. Study findings available in the December issue of Hepatology, a journal published by Wiley-Blackwell … Read more

IL28B gene predicts treatment outcome for liver transplantation patients

German researchers have found a significant association of IL28B genotypes to interferon-based antiviral treatment outcome, and to graft inflammation caused by hepatitis C virus (HCV). The study determined that the presence of G-allele serves as a m…

Obese children experience later mortality post liver transplantation

A new study from the University of Washington reported obese children are at increased mortality risk in later years following primary liver transplantation (LT). Pediatric patients who are thin or severely thin, experience an early mortality risk -…

Hispanics and Asians less likely to receive liver transplants

Researchers at the University of Michigan and Arbor Research Collaborative for Health, both in Ann Arbor, have identified geographic variation as a key factor accounting for disparities in access to liver transplantation among racial and ethnic grou…

Study identifies factors which predict alcohol use after liver transplantation

Patients who receive a liver transplant due to alcoholic liver disease need to demonstrate periods of abstinence and often attend addiction treatment before transplantation. However, alcohol use disorders can recur, as can other diseases requiring t…

Discovery May Dramatically Reduce Liver Transplants in Children

A discovery published in the current issue of The Lancet may lead to new treatments for a deadly liver disease of infancy — dramatically reducing the number of liver transplants in children. A team of researchers at Cincinnati Children’s Hospital have revealed a genetic underpinning to biliary atresia, the most common reason for liver transplant in children. Biliary atresia occurs in infants and usually becomes evident two to eight weeks after birth. Its cause has been unknown. Symptoms include unexplained jaundice, dark urine, clay-colored stools and weight loss. The disease destroys bile ducts in the liver, trapping bile, rapidly causing damage to liver cells and severe scarring.

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