Life & Non-humans

Health of Native Americans on decline before Columbus’ arrival

The health of indigenous people in the Western Hemisphere was on a downward trajectory long before Columbus set foot in the Americas, Ohio researchers say. The rise of agriculture is partly to blame as the demands of tending domestic crops encouraged people to settle in larger communities, where disease was more easily spread. The current research suggests that the overall health of the average person declined with the development of agriculture, government and urbanization.

Insect infestation models may shed light on bug, disease outbreaks

Models of Larch budmoth outbreaks in the European Alps may eventually show scientists how to model a variety of disease and insect eruptions that rely on a combination of enemy, host and spatial movement to decimate populations, according to a team of ecologists. The Larch budmoth feeds on larch trees, a common evergreen variety, consuming the needles and defoliating the branches. In the European Alps, the infestation moves as predictable waves from west to east completely defoliating forests beginning in the French and Italian Alps and moving across the continent through Switzerland and into Austria.

Scientists decipher tooth decay bug’s genome

Researchers in Oklahoma have deciphered the complete genome sequence of Streptococcus mutans, the main organism implicated in causing tooth decay. The work, supported by the National Institute of Dental and Craniofacial Research, has been made freely available online. Said one of the team members involved in the four-year effort: “Building on this basic research may one day lead us to new approaches for preventing and treating tooth decay.” Added another: “By targeting the adherence genes, for example, we might be able to develop a way of preventing S. mutans from sticking to teeth.”

Researchers develop first-ever animal model for a common form of lymphoma

Researchers have developed the world’s first animal model for mature human B-cell lymphomas, a discovery that may lead to the uncovering of the genetic mutations that cause these types of cancer. Mature B-cell type lymphomas account for about 85 percent of all lymphomas, and include both Hodgkin’s and non-Hodgkin’s lymphomas.

Noisy inner life of cells

Within the smoothly operating factory that is the cell, tiny molecular machines carry out their tasks with order and certainty. Or at least that’s what many scientists once believed. In a recent issue of Science, researchers report the first demonstration that bacterial cells intrinsically possess a significant degree of randomness or “noise.” More precisely, they show that key “gene-reading” machines may operate unpredictably, resulting in randomly fluctuating amounts of individual proteins.

Sex, drugs and animal parts: Will Viagra save threatened species?

Viagra may help to save many species of animals and plants that are now endangered due to the demand for animal sexual potency products, according to new research from the University of New South Wales and the University of Alaska. The research suggests that the availability of viagra is having an impact on trade in some of the products, which are used in traditional Chinese medicine to treat impotence, including body parts from seals, deer, green turtles, sea cucumbers, pipefishes, sea horses and geckos.

Treatment preserves bone mass in mice; may help osteoporosis

A completely new type of therapy, using a unique class of synthetic compounds, may someday protect both men and women from the bone-weakening disease osteoporosis. Researchers reported in the October 25 issue of Science that early studies of one of these compounds called estren successfully preserved and even restored bone mass in an animal model without the side effects associated with sex hormone therapies.

Experimental ‘Gene Switch’ Increases Lifespan

By experimentally switching genes off or on at specific stages in an animal’s lifecycle, California scientists have discovered that vigor and lifespan can be significantly extended with no side effects. Many researchers believe that increasing lifespan will dampen reproduction. But the new study of the tiny roundworm commonly known as C. elegans shows that silencing a key gene only in adulthood increases longevity with no effect on reproduction.

NASA to Develop Biohazard ‘Smoke’ Detector

Researchers at NASA’s Jet Propulsion Laboratory, Pasadena, Calif., have demonstrated a prototype device that automatically and continuously monitors the air for the presence of bacterial spores. The result is a novel alarm capability reminiscent of smoke detectors. Current methods for detecting bacterial spores, such as anthrax, require a trained operator. The large number of trained monitors required, with associated costs, limits widespread implementation of these methods.

Isoflavone-enriched soy fails to increase bone density in young women

In a study sure to disappoint the soy industry, researchers say they’ve found that soy protein enriched with isoflavones appears to have no effect on bone mineral content and bone mineral density in young women. Isoflavones are chemicals made by plants, possibly to protect them against oxidation and organisms that might attack them, and soy beans are an especially good source. Isoflavones such as genistein are structurally similar to human estrogens and for that reason have some estrogen-like properties. Scientists and drug companies have become increasingly interested in them over the past few years since the naturally occurring chemicals seem to produce positive effects in bone without the negative impact, such as cancer, that estrogens are believed to have on reproductive organs in some women.

Findings Reconfirm Toxicity of Pfiesteria

Well, it's not exactly helping...You’d think everyone could agree that something as grimly named as Pfiesteria would be toxic. It sure sounds toxic. But a researcher in North Carolina has been at the center of controversy for the last several years because of her claim that the organism does in fact harm fish and is responsible for periodic massive kills. A team at her own school, in fact, refuted her claims, saying when they repeated the experiments they were unable to observe the dinoflagellate microbe forming some of its previously reported toxic life-stages. The ball’s back in Dr. JoAnn Burkholder’s court today, with a new study that her team says refutes the findings published last summer stating that Pfiesteria is not toxic to fish or humans.

New strategy may protect brain against stroke, Parkinson’s and Alzheimer’s

Federal researchers say they’ve developed several drug candidates that show promise in protecting the brain against damage from stroke, with the potential to fight chronic neurodegenerative conditions like Parkinson’s and Alzheimer’s disease as well.. The drugs, called p53 inhibitors, attack a key protein involved in nerve cell death and represent a new strategy for preserving brain function following sudden injury or chronic disease.

Researchers Determine How ‘Hospital Staph’ Resists Antibiotics

Drug-resistant staph infections are a major concern to health care providers. Hospitals in particular have become home to some strains of Staphylococcus aureus that resist every known antibiotic, including the last-resort vancomycin. But two researchers say they’ve discovered just how so-called “Hospital staph” develops resistance, potentially opening the door for development of new drugs that beat it to the punch.

Gene therapy appears to help cancer pain

It’s one of those stories that simultaneously gives great hope but also a little dread. Researchers in Pennsylvania say they’ve successfully stimulated the production of a pain-blocking protein in mice by using a modified herpes virus to attach the appropriate genes onto the animals’ DNA. That’s potentially terrific news. If the same technique held true in humans, it could offer a new way to treat the devastating pain associated with some forms of cancer, such as bone cancer. Of course, a hell of a lot of mice were bred specifically develop the extremely painful bone tumors, just so the technique could be tested. It’s no doubt a necessary sacrifice, but one that shouldn’t be overlooked entirely. You don’t have to be a wacko member of PETA to spare a thought for the millions of mice and other lab animals that are sacrificed each year so humans can live healthier lives.