Health
Pulsed Yamanaka Factors Set Back Epigenic Age
Sinclair opens the paper with an un-footnoted statement that aging consists in accumulated damage, as if this is uncontested and incontrovertible.
Nov 14, 2019
Column
Josh Mitteldorf
Aging & evolutionary biology
Josh Mitteldorf is best known for promoting the theory that aging is not “wearing out” but rather an evolved program that limits lifespan. The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. He began blogging about aging on this site in 2012. His guidance for a long life is at AgingAdvice.org. His two books on aging are available at Amazon and elsewhere.
Mitteldorf’s PhD is in astrophysics. Since about 2020, he has taken up a new challenge as curator and critic of science on the fringe, writing about promising science that the science establishment has unjustly neglected.
In other areas of life, Mitteldorf’s two daughters were among the first girls to be adopted from China in the 1980s. He has taught a weekly yoga class for fifty years. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. Follow his other writing at mitteldorf.substack.com, and listen to his poetry on YouTube.
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Health
Telomeres: The Longer the Better
Mice have much longer telomeres than we do, long enough that telomeres never get critically short in a mouse lifetime.
Oct 29, 2019
Health
Interview with Josh Mitteldorf
Transcript of interview 10/14/19. IP = Ira Pastor, Health and Longevity Ambassador for IdeaXme, founder of BioQuark JJM = Josh Mitteldorf, author of Cracking…
Oct 24, 2019
Health
Methylation Clocks and True Biological Age
The good news is that the DataBETA project has found a home. After several months of seeking a university partner, I am thrilled to be working with Moshe Szyf’s lab at McGill School of Medicine.
Oct 17, 2019
Health
Scaling the Alzheimer’s Cure
This edition of Aging Matters is stolen from . That hour is so packed with actionable information and theoretical background that I found myself going through it slowly to understand and digest it.
Sep 16, 2019
Health
1st Age Reversal Results—Is it HGH or Something Else?
Yesterday, the TRIIM study was described in science news headlines around the world, though, through a glitch, the original research paper is not yet on the Aging Cell web site.
Sep 7, 2019
Health
Rejuvenation at the Cell Level
Cell biologists are within striking distance of “partial reprogramming”. Already, technology has arrived to turn an old cell into a young cell in a Petri dish…
Jul 30, 2019
Health
Money in Aging Research, Part II
Part II : A Survey of For-profit Research Centers How much money is going into aging research?
Jul 15, 2019
Health
Money in Aging Research, Part I
Part I : The Business Culture of Science Since 2000, there has been a 20-fold increase* in research funding for anti-aging medicine.
Jul 1, 2019
Health
Eat Glutathione
Every supplement has its downside. Metformin and rapamycin are the best candidates among fully-developed products, and metformin can dissipate the benefits of exercise, while rapamycin can suppress immune response and raise insulin resistance.
Mar 24, 2019
Health
DNAm GrimAge—the Newest Methylation Clock
Methylation update, Part II Imagine Horvath’s thought process last year, when the PhenoAge clock (described last week) was derived.
Mar 5, 2019
Health
Progress in Methylation-based Aging Clocks
As I wrote last spring, we can efficiently test treatments for aging once we have an objective measure for the rate of aging.
Feb 25, 2019